Diphenyl derivatives from coastal saline soil fungus Aspergillus iizukae

Two new diphenyl derivatives, named iizukines A (1) and B (2), along with nine known compounds were isolated from coastal saline soil derived fungus Aspergillus iizukae. The structures were determined by extensive spectroscopic analysis. Their cytotoxicities were preliminarily evaluated on HL-60, BE...

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Bibliographic Details
Published in:Archives of pharmacal research 2015, 38(6), , pp.1038-1043
Main Authors: Liu, Desheng, Yan, Ling, Ma, Liying, Huang, Yuling, Pan, Xiaohong, Liu, Weizhong, Lv, Zhihua
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Aspergillus
Aspergillus - chemistry
biphenyl
Biphenyl Compounds - isolation & purification
Biphenyl Compounds - pharmacology
Cell Line, Tumor
cytotoxicity
Drug Screening Assays, Antitumor
Fermentation
HL-60 Cells
Humans
Magnetic Resonance Spectroscopy
Medicine
Models, Molecular
Molecular Conformation
Pharmacology/Toxicology
Pharmacy
Research Article
saline soils
soil fungi
Soil Microbiology
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
spectroscopy
X-Ray Diffraction
약학
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Summary:Two new diphenyl derivatives, named iizukines A (1) and B (2), along with nine known compounds were isolated from coastal saline soil derived fungus Aspergillus iizukae. The structures were determined by extensive spectroscopic analysis. Their cytotoxicities were preliminarily evaluated on HL-60, BEL-7402 and A-549 cell lines by the MTT assay.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-014-0371-z