Inhibitory effect of polyozellin on secretory group IIA phospholipase A2

The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) is enhanced by development of inflammatory disorders. In this study, sPLA2-IIA expression was induced in the lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells and mice to evaluate the effect of polyozellin. P...

Full description

Saved in:
Bibliographic Details
Published in:Archives of pharmacal research 2016, 39(2), , pp.271-278
Main Authors: Ku, Sae-Kwang, Yang, Eun-Ju, Kang, Hyejin, Jung, Byeongjin, Bae, Jong-Sup
Format: Article
Language:English
Subjects:
Agaricales - chemistry
Animals
anti-inflammatory activity
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
antioxidant activity
Cells, Cultured
Cyclooxygenase 2 - metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
Extracellular Signal-Regulated MAP Kinases - metabolism
Furans - isolation & purification
Furans - pharmacology
Group II Phospholipases A2 - antagonists & inhibitors
Group II Phospholipases A2 - metabolism
human umbilical vein endothelial cells
Human Umbilical Vein Endothelial Cells - drug effects
Human Umbilical Vein Endothelial Cells - enzymology
inflammation
lipopolysaccharides
Lipopolysaccharides - pharmacology
Male
Medicine
mice
Mice, Inbred ICR
mitogen-activated protein kinase
mushrooms
Pharmacology/Toxicology
Pharmacy
phospholipase A2
Phosphorylation
Prostaglandin-E Synthases - metabolism
protein synthesis
Research Article
Sepsis - drug therapy
Sepsis - enzymology
Sepsis - microbiology
Time Factors
약학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) is enhanced by development of inflammatory disorders. In this study, sPLA2-IIA expression was induced in the lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells and mice to evaluate the effect of polyozellin. Polyozellin, a major constituent of a Korea edible mushroom Polyozellus multiplex, has been known to exhibit the biological activities such as anti-oxidative and anti-inflammatory effects. Polyozellin remarkably suppressed the LPS-mediated protein expression and activity of sPLA2-IIA via inhibition of phosphorylation of cytosolic phospholipase A2 and extracellular signal-regulated kinase 1/2. These results demonstrated that polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-015-0694-4