miR-7641 modulates the expression of CXCL1 during endothelial differentiation derived from human embryonic stem cells

MicroRNAs (miRNAs) are a class of small noncoding RNAs that negatively regulate gene expression through binding to 3′ untranslated region. We identified and characterized the novel miRNA, miR-7641, in human mesenchymal stem cells. The expression of miR-7641 was downregulated during differentiation f...

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Bibliographic Details
Published in:Archives of pharmacal research 2013, 36(3), , pp.353-358
Main Authors: Yoo, Jung Ki, Jung, Ho Yong, Kim, Chang-Hyun, Son, Woo Sung, Kim, Jin Kyeoung
Format: Article
Language:English
Subjects:
Base Sequence
Cell Differentiation - physiology
Cells, Cultured
Chemokine CXCL1 - biosynthesis
Chemokine CXCL1 - genetics
Embryonic Stem Cells - physiology
Gene Expression Regulation
Humans
Medicine
MicroRNAs - genetics
MicroRNAs - physiology
Molecular Sequence Data
Pharmacology/Toxicology
Pharmacy
Research Article
약학
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Summary:MicroRNAs (miRNAs) are a class of small noncoding RNAs that negatively regulate gene expression through binding to 3′ untranslated region. We identified and characterized the novel miRNA, miR-7641, in human mesenchymal stem cells. The expression of miR-7641 was downregulated during differentiation from human embryonic stem cells to endothelial cells. The CXCL1, a member of the CXC chemokine family, is known as promoting neovascularization by binding G-protein coupled receptors and is related to endothelial cells biogenesis such as angiogenesis, and it was predicted as target gene of miR-7641 by computerized analysis and the luciferase reporter assay. The miR-7641 significantly suppressed CXCL1 of transcriptional and post-translational levels. These data suggest that miR-7641 might be related with differentiation of human endothelial cells.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-013-0067-9