Attenuation of scopolamine-induced cognitive dysfunction by obovatol

• Published in: Archives of pharmacal research 2012, 35(7), , pp.1279-1286
• Main Authors: Choi, Dong-Young, Lee, Young-Jung, Lee, Sun Young, Lee, Yoot Mo, Lee, Hyun Hee, Choi, Im Seop, Oh, Ki-Wan, Han, Sang Bae, Nam, Sang-Yoon, Hong, Jin Tae
• Format: Article
• Language: English
• Subjects: Acetylcholinesterase - metabolism; Amnesia - chemically induced; Amnesia - enzymology; Amnesia - prevention & control; Amnesia - psychology; Amyloid beta-Peptides - metabolism; Animals; Behavior, Animal - drug effects; Cerebral Cortex - drug effects; Cerebral Cortex - enzymology; Cognition - drug effects; Cognition Disorders - chemically induced; Cognition Disorders - enzymology; Cognition Disorders - prevention & control; Cognition Disorders - psychology; Disease Models, Animal; Dose-Response Relationship, Drug; GPI-Linked Proteins - metabolism; Hippocampus - drug effects; Hippocampus - enzymology; Male; Medicine; Memory - drug effects; Mice; Mice, Inbred ICR; Motor Activity - drug effects; Nootropic Agents - pharmacology; Pharmacology/Toxicology; Pharmacy; Phenyl Ethers - pharmacology; Scopolamine Hydrobromide; Time Factors; 약학
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/s12272-012-0719-1

Alzheimer’s disease (AD) is the most prevalent cause of dementia in the elderly people. The disease is pathologically characterized by extracellular deposition of beta-amyloid peptide (Aβ), cholinergic neurodegeneration and elevation of acetylcholine esterase (AChE) activity in the affected regions. In this study, we investigated the effects of obovatol on memory dysfunction, which was caused by scopolamine. Obovatol (0.2, 0.5 and 1 mg/kg for 7 day) attenuated scopolamine (1 mg/kg, i.p.)-induced amnesia in a dose-dependent manner, as revealed by the Morris water maze test and step-through passive avoidance test. Mechanism studies exhibited that obovatol dose-dependently alleviated scopolamine-induced increase in Aβ generation and β-secretase activity in the cortex and hippocampus. Obovatol also attenuated scopolamine-induced rise in AChE activity in the cortex and hippocampus. Obovatol might rescue scopolamine-mediated impaired learning and memory function by attenuating Aβ accumulation and stabilizing cholinergic neurotransmission, which suggests that the natural compound could be a useful agent for the prevention of the development or progression of AD neurodegeneration.