A new phenolic compound with anticancer activity from the wood of Millettia leucantha

A new phenolic compound, 1-(3-hydroxy-4-methoxyphenyl)-3-(2,4-dihydroxy-5-methoxyphenyl) propan-1-ol, named as millettinol ( 1 ), along with six known compounds, medicarpin ( 2 ), 4-hydroxy-3-methoxy-8,9-methylenedioxypterocarpan ( 3 ), 5,4′-dihydroxy-7,8-dimethoxyisoflavone ( 4 ), physcion ( 5 ), (...

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Bibliographic Details
Published in:Archives of pharmacal research 2011, 34(6), , pp.881-886
Main Authors: Rayanil, Kanok-on, Bunchornmaspan, Pastraporn, Tuntiwachwuttikul, Pittaya
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Medicine
Millettia - chemistry
Pharmacology/Toxicology
Pharmacy
Phenols - administration & dosage
Phenols - isolation & purification
Phenols - pharmacology
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Propanols - administration & dosage
Propanols - isolation & purification
Propanols - pharmacology
Spectrum Analysis
Wood
약학
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Summary:A new phenolic compound, 1-(3-hydroxy-4-methoxyphenyl)-3-(2,4-dihydroxy-5-methoxyphenyl) propan-1-ol, named as millettinol ( 1 ), along with six known compounds, medicarpin ( 2 ), 4-hydroxy-3-methoxy-8,9-methylenedioxypterocarpan ( 3 ), 5,4′-dihydroxy-7,8-dimethoxyisoflavone ( 4 ), physcion ( 5 ), ( R )-(-)-mellein ( 6 ) and isoliquiritigenin ( 7 ), were isolated from the wood of Millettia leucantha . The structures of the compounds were determined by an analysis of their spectroscopic data. Some of the isolates were tested for anticancer activity. Compound 1 exhibited strong cytotoxicity against the BCA-1 tumor cell lines with an IC 50 = 3.44 μg/mL.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-011-0603-4