Dysfunction of endothelial progenitor cells under diabetic conditions and its underlying mechanisms

Cardiovascular complications have been major concerns in the treatment of diabetes, and up to 80% of all deaths in diabetic patients are linked to cardiovascular problems. Impaired angiogenesis is one of the most serious symptoms associated with diabetes, resulting in delayed wound healing and lower...

Full description

Saved in:
Bibliographic Details
Published in:Archives of pharmacal research 2012, 35(2), , pp.223-234
Main Authors: Kim, Kyeong-A, Shin, Young-Jun, Kim, Jeong-Hyeon, Lee, Hanna, Noh, Sun-Young, Jang, Seung-Hoon, Bae, Ok-Nam
Format: Article
Language:English
Subjects:
Adult Stem Cells - drug effects
Adult Stem Cells - physiology
Animals
Cardiovascular Diseases - complications
Cardiovascular Diseases - physiopathology
Cell Differentiation - physiology
Diabetes Complications - physiopathology
Epithelial Cells - physiology
Humans
Medicine
Neovascularization, Physiologic - physiology
Pharmacology/Toxicology
Pharmacy
Review
Signal Transduction - physiology
약학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiovascular complications have been major concerns in the treatment of diabetes, and up to 80% of all deaths in diabetic patients are linked to cardiovascular problems. Impaired angiogenesis is one of the most serious symptoms associated with diabetes, resulting in delayed wound healing and lower limb amputation. Endothelial progenitor cells (EPCs), a subpopulation of adult stem cells, are recruited from bone marrow to the injured vessel to promote endothelial regeneration and neovascularization, playing an important role in angiogenesis. Interestingly, several clinical studies have showed that the number of recruited EPCs is reduced and their function is decreased under diabetic conditions, implying that diabetic EPC dysfunction may contribute to defective angiogenesis and resultant cardiovascular complications in diabetes. To recover the functional abilities of diabetic EPCs and to address possible application of EPC cell therapy to diabetic patients, some studies provided explanations for diabetic EPC dysfunction including increased oxidative stress, involvement of the inflammatory response, alteration in the nitric oxide pathway and reduced signals for EPC recruitment. This review discusses clinical evidence of impairment of EPC functions under diabetic conditions and the suggested mechanisms for diabetic EPC dysfunction.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-012-0203-y