Two new triterpenoid acids from Kadsura coccinea

An investigation of EtOAc extracts of Kadsura coccinea (Lem.) A. C. Smith, has led to the isolation of two new compounds characterized as 3-hydroxy-12-hydroxyl coccinic acid ( 1 ) and 3-hydroxy-neokadsuranic acid A ( 2 ). Their structures were established by 1D and 2D NMR techniques and mass spectro...

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Bibliographic Details
Published in:Archives of pharmacal research 2010, 33(12), , pp.1933-1936
Main Authors: Song, Yan, Zhao, Qing-Jie, Jin, Yong-Sheng, Feng, Chuan-Wei, Chen, Hai-Sheng
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Cell Line, Tumor
Cell Proliferation - drug effects
HCT116 Cells
Hep G2 Cells
HL-60 Cells
Humans
Kadsura
Magnetic Resonance Spectroscopy
Medicine
Pharmacology/Toxicology
Pharmacy
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Roots
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
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Summary:An investigation of EtOAc extracts of Kadsura coccinea (Lem.) A. C. Smith, has led to the isolation of two new compounds characterized as 3-hydroxy-12-hydroxyl coccinic acid ( 1 ) and 3-hydroxy-neokadsuranic acid A ( 2 ). Their structures were established by 1D and 2D NMR techniques and mass spectroscopy. Antiproliferative effects of the isolated compounds were evaluated against four human tumor cell lines (A549, HCT116, HL-60 and HepG2), and it was found that compound 1 exhibited antiproliferative effects with IC 50 values ranging from 3.01 to 18.08 μg/mL.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-010-1207-0