The combination of naproxen and citral reduces nociception and gastric damage in rats

It has been shown that the association of non-steroidal anti-inflammatory drugs with plant extracts can increase their antinociceptive activity, allowing the use of lower doses and, thus, limiting side effects. Therefore, the aim of this study was to examine the effects of the interaction between na...

Full description

Saved in:
Bibliographic Details
Published in:Archives of pharmacal research 2010, 33(10), , pp.1691-1697
Main Authors: Ortiz, Mario I., Ramírez-Montiel, Martha L., González-García, Martha P., Ponce-Monter, Héctor A., Castañeda-Hernández, Gilberto, Cariño-Cortés, Raquel
Format: Article
Language:English
Subjects:
Analgesics - adverse effects
Analgesics - therapeutic use
Animals
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Behavior, Animal - drug effects
Dose-Response Relationship, Drug
Drug Synergism
Drug Therapy, Combination
Gastric Mucosa - drug effects
Medicine
Monoterpenes - adverse effects
Monoterpenes - therapeutic use
Naproxen - adverse effects
Naproxen - therapeutic use
Pain Measurement
Pharmacology/Toxicology
Pharmacy
Rats
Rats, Wistar
Severity of Illness Index
Stomach Ulcer - chemically induced
Stomach Ulcer - prevention & control
약학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It has been shown that the association of non-steroidal anti-inflammatory drugs with plant extracts can increase their antinociceptive activity, allowing the use of lower doses and, thus, limiting side effects. Therefore, the aim of this study was to examine the effects of the interaction between naproxen and citral on nociception and gastric injury in rats. Naproxen, citral, or combinations of naproxen and citral produced an antinociceptive effect. The administration of naproxen produced significant gastric damage, but this effect was not obtained with either citral or the naproxen-citral combination. The ED 50 value was estimated for the individual drugs and an isobologram was constructed. The derived theoretical ED 50 for the antinociceptive effect (423.8 mg/kg) was not significantly different from the observed experimental value (359.0 mg/kg); hence, the interaction between naproxen and citral mediating the antinociceptive effect is additive. These data suggest that the naproxen-citral combination interacts at the systemic level, produces minor gastric damage, and potentially has therapeutic advantages for the clinical treatment of inflammatory pain.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-010-1020-9