A new triterpenoid from Brucea javanica

A new triterpenoid, bruceajavanin C ( 1 ), together with bruceosides A and B ( 2 and 3 ), bruceines D and E ( 4 and 5 ), yadanziosides A and G ( 6 and 7 ), (20R)-O-(3)-α-L-arabinopyranosylpregn-5-ene-3β,20-diol ( 8 ), and α-D-glucopyranoside, (3β, 20R)-3-hydroxypregn-5-en-20-yl ( 9 ) were isolated f...

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Bibliographic Details
Published in:Archives of pharmacal research 2009, 32(5), , pp.661-666
Main Authors: Liu, Jian Hua, Qin, Jiang Jiang, Jin, Hui Zi, Hu, Xiao Jia, Chen, Ming, Shen, Yun Heng, Yan, Shi Kai, Zhang, Wei Dong
Format: Article
Language:English
Subjects:
Animals
Brucea - chemistry
Cell Line
Lipopolysaccharides - pharmacology
Macrophages - drug effects
Macrophages - metabolism
Magnetic Resonance Spectroscopy
Medicine
Mice
Molecular Structure
Nitric Oxide - metabolism
Pharmacology/Toxicology
Pharmacy
Plant Components, Aerial
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
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Summary:A new triterpenoid, bruceajavanin C ( 1 ), together with bruceosides A and B ( 2 and 3 ), bruceines D and E ( 4 and 5 ), yadanziosides A and G ( 6 and 7 ), (20R)-O-(3)-α-L-arabinopyranosylpregn-5-ene-3β,20-diol ( 8 ), and α-D-glucopyranoside, (3β, 20R)-3-hydroxypregn-5-en-20-yl ( 9 ) were isolated from the aerial parts of Brucea javanica . The structure of 1 was elucidated on the basis of 2D-NMR spectroscopic analysis. In addition, compounds 1 , 3 , 4 , 5 , and 6 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-009-1503-8