Farnesyl protein transferase inhibitory components of Polygonum multiflorum

The methanolic extract of the roots of Polygonum multiflorum (Polygonaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone glycosides, as inhibitors of FPTase....

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Bibliographic Details
Published in:Archives of pharmacal research 2009, 32(4), , pp.495-499
Main Authors: Kwon, Byoung-Mog, Kim, Sung-Hoon, Baek, Nam-In, Lee, Sa Im, Kim, Eun Jeong, Yang, Jae Heon, Chae, Byeong Suk, Lee, Jae Hyeok, Park, Hee Wook, Park, Jeong-Suk, Kim, Dae Keun
Format: Article
Language:English
Subjects:
Alkyl and Aryl Transferases - antagonists & inhibitors
Anthraquinones - chemistry
Anthraquinones - isolation & purification
Anthraquinones - pharmacology
Biological Assay
Chemical Fractionation
Dose-Response Relationship, Drug
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Medicine
Methanol - chemistry
Molecular Structure
Pharmacology/Toxicology
Pharmacy
Plant Roots
Polygonum - chemistry
Solvents - chemistry
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Summary:The methanolic extract of the roots of Polygonum multiflorum (Polygonaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone glycosides, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-009-1403-y