Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases

Nitric oxide (NO) is a pivotal signaling messenger in the cardiovascular system. NO participates in regulatory functions including control of hemostasis, fibrinolysis, platelet and leukocyte interactions with the arterial wall, regulation of vascular tone, proliferation of vascular smooth muscle cel...

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Bibliographic Details
Published in:Archives of pharmacal research 2009, 32(8), , pp.1103-1108
Main Authors: Napoli, Claudio, Ignarro, Louis J.
Format: Article
Language:English
Subjects:
Animals
Humans
Kruppel-Like Transcription Factors - physiology
Medicine
Nitric Oxide - physiology
Nitric Oxide Synthase Type III - genetics
Nitric Oxide Synthase Type III - physiology
Oxidation-Reduction
Pharmacology/Toxicology
Pharmacy
Vascular Diseases - etiology
약학
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Summary:Nitric oxide (NO) is a pivotal signaling messenger in the cardiovascular system. NO participates in regulatory functions including control of hemostasis, fibrinolysis, platelet and leukocyte interactions with the arterial wall, regulation of vascular tone, proliferation of vascular smooth muscle cells, and homeostasis of blood pressure. Diminished NO bioavailability and abnormalities in NO-dependent signaling are among central factors of vascular disease, although it is unclear whether this is a cause of, or result of endothelial dysfunction or both pathogenic events. Disturbances in NO bioavailability have been linked to cause endothelial dysfunction, leading to increased susceptibility to atherosclerotic lesion progression, hypertension, hypercholesterolemia, diabetes mellitus, thrombosis and stroke.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-009-1801-1