Two new hetero-spirocyclic γ-lactam derivatives from marine sediment-derived fungus Aspergillus sydowi D2–6

Two new hetero-spirocyclic γ-lactams, azaspirofurans A ( 1 ) and B ( 2 ), had been isolated from a marine sediment-derived fungus Aspergillus sydowi D2–6. Their structures were determined by the chemical evidence and spectral analyses. Compound 1 exhibited cytotoxicity against A549 cell line with th...

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Bibliographic Details
Published in:Archives of pharmacal research 2010, 33(4), , pp.499-502
Main Authors: Ren, Hong, Liu, Rui, Chen, Li, Zhu, Tianjiao, Zhu, Wei Ming, Gu, Qian Qun
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Aspergillus - growth & development
Aspergillus - isolation & purification
Aspergillus - metabolism
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Dose-Response Relationship, Drug
Geologic Sediments - microbiology
Humans
Inhibitory Concentration 50
Lactams - isolation & purification
Lactams - pharmacology
Medicine
Mice
Molecular Structure
Pharmacology/Toxicology
Pharmacy
Pyrrolidinones - isolation & purification
Pyrrolidinones - pharmacology
Spiro Compounds - isolation & purification
Spiro Compounds - pharmacology
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Summary:Two new hetero-spirocyclic γ-lactams, azaspirofurans A ( 1 ) and B ( 2 ), had been isolated from a marine sediment-derived fungus Aspergillus sydowi D2–6. Their structures were determined by the chemical evidence and spectral analyses. Compound 1 exhibited cytotoxicity against A549 cell line with the IC50 value of 10 μM by MTT method.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-010-0401-4