Inhibition of prostaglandin E2 production by synthetic Wogonin analogs

Effects of wogonin analogs on cyclooxygenase-2 (COX-2) catalyzed prostaglandin E 2 production on lipopolysaccharide (LPS)-induced RAW 264.7 cells were investigated. Wogonin analogs were prepared via several different synthetic pathways. Among wogonin analogs tested, 8-halogeno and 8-nitro analogs sh...

Full description

Saved in:
Bibliographic Details
Published in:Archives of pharmacal research 2009, 32(11), , pp.1503-1508
Main Authors: Gurung, Santosh K., Kim, Hyun Pyo, Park, Haeil
Format: Article
Language:English
Subjects:
Animals
Cell Line
Cyclooxygenase 2 - drug effects
Cyclooxygenase 2 Inhibitors - chemical synthesis
Cyclooxygenase 2 Inhibitors - chemistry
Cyclooxygenase 2 Inhibitors - pharmacology
Dinoprostone - antagonists & inhibitors
Dinoprostone - biosynthesis
Flavanones - chemical synthesis
Flavanones - chemistry
Flavanones - pharmacology
Lipopolysaccharides
Macrophages - drug effects
Macrophages - metabolism
Medicine
Mice
Pharmacology/Toxicology
Pharmacy
Structure-Activity Relationship
약학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Effects of wogonin analogs on cyclooxygenase-2 (COX-2) catalyzed prostaglandin E 2 production on lipopolysaccharide (LPS)-induced RAW 264.7 cells were investigated. Wogonin analogs were prepared via several different synthetic pathways. Among wogonin analogs tested, 8-halogeno and 8-nitro analogs showed strong inhibitory activities against COX-2 catalyzed PGE 2 production from LPS-induced RAW 264.7 cells. Effect of wogonin was largely dependent on structural alteration of the 8-methoxy group.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-009-2101-5