Neuroprotective effects of chronic hesperetin administration in mice

Flavonoids are considered therapeutic agents in neurodegenerative disease because of their neuroprotective activity. This study investigated the neuroprotective effects of hesperetin in the brains of mice administered hesperetin at 10 or 50 mg/kg body weight (BW) for five weeks. Hesperetin inhibited...

Full description

Saved in:
Bibliographic Details
Published in:Archives of pharmacal research 2008, 31(11), , pp.1457-1462
Main Authors: Choi, Eun Jeong, Ahn, Woong Shick
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Blotting, Western
Brain Chemistry - drug effects
Catalase - metabolism
Female
Glutathione - metabolism
Hesperidin - pharmacology
Medicine
Mice
Mice, Inbred ICR
Neuroprotective Agents
Oxidative Stress - drug effects
Pharmacology/Toxicology
Pharmacy
Protein Carbonylation - drug effects
Research Article
Superoxide Dismutase - metabolism
Thiobarbituric Acid Reactive Substances - metabolism
약학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Flavonoids are considered therapeutic agents in neurodegenerative disease because of their neuroprotective activity. This study investigated the neuroprotective effects of hesperetin in the brains of mice administered hesperetin at 10 or 50 mg/kg body weight (BW) for five weeks. Hesperetin inhibited biomarkers of oxidative stress, such as the level of thiobarbituric acid-reactive substance (TBARS) and carbonyl content, although there was a significant reduction at the higher dose of hesperetin. Moreover, at the higher dose, hesperetin significantly activated the catalase and total superoxide dismutase (SOD) activities. The same patterns were observed in the protein expression, and the expression of CuZn-SOD was more pronounced than that of Mn-SOD. The reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio was increased significantly in a dose-dependent manner, as well as the glutathione peroxidase (GSH-px) and glutathione reductase (GR) activities. Moreover, hesperetin did not induce apoptosis, even at the higher dose, as evidenced by caspase-3 expression and its activity. Based on these results, hesperetin may have a neuroprotective effect via the inhibition of oxidative damage, together with activation of the antioxidant enzyme system.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-001-2130-1