Cytotoxic terpenes and lignans from the roots of Ainsliaea acerifolia

The chromatographic separation of the MeOH extract of the roots of Ainsliaea acerifolia (Compositae) led to the isolation of six known terpenes and two known lignans. Their structures were identified by spectroscopic methods as mokko lactone (1), betulonic acid (2), betulinic acid (3), zaluzanin C (...

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Bibliographic Details
Published in:Archives of pharmacal research 2006, 29(3), , pp.203-208
Main Authors: Choi, Sang Zin, Yang, Min Cheol, Choi, Sang Un, Lee, Kang Ro
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Asteraceae - chemistry
Cell Line, Tumor
Cell Proliferation - drug effects
Humans
Inhibitory Concentration 50
Lignans - chemistry
Lignans - isolation & purification
Lignans - pharmacology
Oleanolic Acid - analogs & derivatives
Oleanolic Acid - chemistry
Oleanolic Acid - isolation & purification
Oleanolic Acid - pharmacology
Plant Roots - chemistry
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Sesquiterpenes, Guaiane
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
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Summary:The chromatographic separation of the MeOH extract of the roots of Ainsliaea acerifolia (Compositae) led to the isolation of six known terpenes and two known lignans. Their structures were identified by spectroscopic methods as mokko lactone (1), betulonic acid (2), betulinic acid (3), zaluzanin C (4), 1beta-hydroperoxygermacra-4(15),5,10(14)-triene (5), pluviatilol (6), (+)-syringaresinol (7), and glucozaluzanin C (8). Compounds 1 approximately 4 and 8 showed non-specific significant cytotoxicity against five human tumor cell lines with ED50 values ranging from 0.36 approximately 5.54 microg/mL.
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02969394