Anti-inflammatory activity of flavonoids from Populus davidiana

An in vitro bioassay-guide revealed that the methanol (MeOH) extract of the stem bark of Populus davidiana showed considerable inhibitory activity against cyclooxygenase (COX-1, COX-2). Continuous phytochemical study of the MeOH extract of this plant led to the isolation of ten flavonoids; sakuranet...

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Bibliographic Details
Published in:Archives of pharmacal research 2006, 29(12), , pp.1102-1108
Main Authors: Zhang, XinFeng, Hung, Tran Manh, Phuong, Phuong Thien, Ngoc, Tran Minh, Min, Byung-Sun, Song, Kyung-Sik, Seong, Yeon Hee, Bae, KiHwan
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Cyclooxygenase 1 - metabolism
Cyclooxygenase 2 Inhibitors - isolation & purification
Cyclooxygenase 2 Inhibitors - pharmacology
Cyclooxygenase Inhibitors - isolation & purification
Cyclooxygenase Inhibitors - pharmacology
Enzyme Inhibitors - pharmacology
Flavonoids - isolation & purification
Flavonoids - pharmacology
Hydrolysis
Magnetic Resonance Spectroscopy
Plant Bark - chemistry
Plant Extracts - analysis
Populus - chemistry
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Superoxides - metabolism
Xanthine Oxidase - antagonists & inhibitors
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Summary:An in vitro bioassay-guide revealed that the methanol (MeOH) extract of the stem bark of Populus davidiana showed considerable inhibitory activity against cyclooxygenase (COX-1, COX-2). Continuous phytochemical study of the MeOH extract of this plant led to the isolation of ten flavonoids; sakuranetin (1), rhamnocitrin (2), 7-O-methylaromadendrin (3), naringenin (4), eriodictyol (5), aromadendrin (6), kaempferol (7), neosakuranin (8), sakuranin (9) and sakurenetin-5,4'-di-beta-D-glucopyranoside (10). Their structures were identified on the basis of their physicochemical and spectroscopic analyses. The isolated compounds, 1-10, were tested for their inhibitory activities against COX-1 and COX-2. Compound 7 was found to have potent inhibitory effect on COX-1 and a moderate effect on COX-2, meanwhile, compounds 1-6 showed moderate inhibition against COX-1 only. Moreover, compounds 5-8 exhibited suppressive effects on xanthine oxidase (XO). These results may explain, in part, the traditional uses of P. davidiana in ethnomedicine.
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02969299