Stereoselective Synthesis of L-threo-Sphingosine, L-threo-Sphinganine, D-threo-Sphingosine

In this study, we explored a convenient and concise route for synthesis of L-threo-sphingosine, D-threo-sphingosine, L-threo-sphinganine and D-threo-sphinganine from commercially available L- or D-serine. The key steps are the simple preparation of trans-oxazoline and intermolecular olefin cross met...

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Bibliographic Details
Published in:Archives of pharmacal research 2007, 30(2), , pp.167-171
Main Authors: Yong-Shou Tian, Jae-Eun Joo, Van-Thoai Pham, Kee-Young Lee, Won-Hun Ham
Format: Article
Language:Korean
Subjects:
약학
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Summary:In this study, we explored a convenient and concise route for synthesis of L-threo-sphingosine, D-threo-sphingosine, L-threo-sphinganine and D-threo-sphinganine from commercially available L- or D-serine. The key steps are the simple preparation of trans-oxazoline and intermolecular olefin cross metathesis. KCI Citation Count: 18
ISSN:0253-6269
1976-3786