Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa

Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocoryno...

Full description

Saved in:
Bibliographic Details
Published in:Archives of pharmacal research 2007, 30(2), , pp.151-154
Main Authors: Choi, Sang Un, Baek, Nam-In, Kim, Sung-Hoon, Yang, Jae Heon, Eun, Jae Soon, Shin, Tae Yong, Lim, Jong Pil, Lee, Jae Hyeok, Jeon, Hoon, Yun, Mi-Young, Leem, Kang-Hyun, Park, Hee Wook, Kim, Dae Keun
Format: Article
Language:English
Subjects:
Alkaloids - isolation & purification
Alkaloids - pharmacology
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Cell Adhesion - drug effects
Cell Line, Tumor
Cell Survival - drug effects
Corydalis - chemistry
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Isoquinolines - isolation & purification
Isoquinolines - pharmacology
Molecular Structure
Neutrophils - cytology
Plant Components, Aerial - chemistry
Structure-Activity Relationship
약학
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells.
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02977687