Synthesis and cytotoxicity of new 3-alkyl-1-(1-methyl-2-phenylethyl)ureas related to ceramide

A series of new 3-alkyl-1-(1-methyl-2-phenylethyl)ureas related to ceramide was synthesized and evaluated for their in vitro cytotoxic activity against five human tumor cell lines. The urea analogue (2b) of B13 showed comparable or slightly more potent cytotoxic activity as compared to B13, indicati...

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Bibliographic Details
Published in:Archives of pharmacal research 2003, 26(4), , pp.270-274
Main Authors: Lim, Sejin, Ryu, Jae Hark, Im, Chaeuk, Yim, Chul Bu
Format: Article
Language:English
Subjects:
Ceramides - physiology
Colonic Neoplasms
Drug Screening Assays, Antitumor
Humans
In Vitro Techniques
Kidney Neoplasms
Leukemia
Lung Neoplasms
Male
Prostatic Neoplasms
Tumor Cells, Cultured - drug effects
Urea - analogs & derivatives
Urea - chemical synthesis
Urea - metabolism
Urea - pharmacology
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Summary:A series of new 3-alkyl-1-(1-methyl-2-phenylethyl)ureas related to ceramide was synthesized and evaluated for their in vitro cytotoxic activity against five human tumor cell lines. The urea analogue (2b) of B13 showed comparable or slightly more potent cytotoxic activity as compared to B13, indicating that urea does appear to serve as a bioisostere of amide.
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02976954