Anti-oxidant activities of Acanthopanax senticosus stems and their lignan components

• Published in: Archives of pharmacal research 2004, 27(1), , pp.106-110
• Main Authors: Lee, Sanghyun, Son, Dongwook, Ryu, Jiyoung, Lee, Yeon Sil, Jung, Sang Hoon, Kang, Jungil, Lee, Sang Yun, Kim, Hyun-Su, Shin, Kuk Hyun
• Format: Article
• Language: English
• Subjects: Administration, Oral; Alanine Transaminase - blood; Alanine Transaminase - drug effects; Animals; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Aspartate Aminotransferases - blood; Aspartate Aminotransferases - drug effects; Biphenyl Compounds; Butanols - administration & dosage; Butanols - chemistry; Butanols - pharmacokinetics; Carbon Tetrachloride Poisoning - drug therapy; Carbon Tetrachloride Poisoning - metabolism; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical - methods; Eleutherococcus - chemistry; Free Radical Scavengers - metabolism; Free Radical Scavengers - pharmacology; Glucosides - administration & dosage; Glucosides - chemistry; Glucosides - pharmacokinetics; Hepatocytes - drug effects; Hepatocytes - metabolism; Hepatocytes - pathology; Indicators and Reagents; Lignans - chemistry; Lignans - isolation & purification; Lignans - pharmacology; Male; Phenylpropionates - administration & dosage; Phenylpropionates - chemistry; Phenylpropionates - pharmacokinetics; Picrates - antagonists & inhibitors; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Stems - chemistry; Rats; Rats, Sprague-Dawley; Silymarin - administration & dosage; Silymarin - pharmacokinetics; Silymarin - therapeutic use; Solubility; Water - chemistry; 약학
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/BF02980055

The antioxidant activities of Acanthopanax senticosus stems were evaluated in CCl4-intoxicated rats. The n-butanol fraction from the water extract of the stems, when pretreated orally at 200 mg/kg/day for 7 consecutive days in rats, was demonstrated to exhibit significant increases in antioxidant enzyme activities such as hepatic cytosolic superoxide dismutase, catalase and glutathione peroxidase by 30.31, 19.82 and 155%, respectively. The n-butanol fraction whereas showed a significant inhibition of serum GPT activity (65.79% inhibition) elevated with hepatic damage induced by CCl4-intoxication. Eleutheroside B, a lignan component, isolated from the n-butanol fraction was found to cause a moderate free radical scavenging effect on DPPH, its scavenging potency as indicated in IC50 value, being 58.5 microM. These results suggested that the stems of A. senticosus possess not only antioxidant but also hepatoprotective activities.