Cytotoxic sesquiterpene lactones from Saussurea calcicola

Seven sesquiterpene lactones were isolated by the chromatographic separation of the MeOH extract of the aerial parts of Saussurea calcicola (Compositae). Their structures were determined spectroscopically to be cynaropicrin (1), arguerin B (2), cebellin F (3), 8alpha-hydroxy-11alpha, 13-dihydrozaluz...

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Bibliographic Details
Published in:Archives of pharmacal research 2005, 28(10), , pp.1142-1146
Main Authors: Choi, Sang Zin, Choi, Sang Un, Lee, Kang Ro
Format: Article
Language:English
Subjects:
Asteraceae - chemistry
Cell Line, Tumor
Cell Survival - drug effects
Dose-Response Relationship, Drug
Humans
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Structure-Activity Relationship
약학
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Summary:Seven sesquiterpene lactones were isolated by the chromatographic separation of the MeOH extract of the aerial parts of Saussurea calcicola (Compositae). Their structures were determined spectroscopically to be cynaropicrin (1), arguerin B (2), cebellin F (3), 8alpha-hydroxy-11alpha, 13-dihydrozaluzanin C (4), desacylcynaropicrin (5), 3beta-hydroxy-8alpha-epoxymethylacriloiloxy-4(15),10(14),11(13)-trien-guaian-6,12-olide (6), and kandavanolide (7). Compounds 1 and 2 showed significant cytotoxicity against five cultured human tumor cell lines with ED50 values ranging from 0.23-1.72 microg/mL.
ISSN:0253-6269
1976-3786
DOI:10.1007/bf02972976