Distribution of organochlorines and PCB congeners in Korean human tissues

• Published in: Archives of pharmacal research 2005, 28(7), , pp.829-838
• Main Authors: Park, Mee-Jung, Lee, Sang-Ki, Yang, Ja-Yeol, Kim, Ki-Wook, Lee, Su-Yeon, Lee, Won-Tae, Chung, Kyu-Hyuck, Yun, Yeo-Pyo, Yoo, Young-Chan
• Format: Article
• Language: English
• Subjects: adipose tissue; Adipose Tissue - chemistry; Adipose Tissue - metabolism; Adolescent; Adult; Age Factors; Aged; aldrin; Asian Continental Ancestry Group; blood; correlation; cortex; DDE; elderly; endrin; Female; HCH (pesticide); Humans; Hydrocarbons, Chlorinated - analysis; Hydrocarbons, Chlorinated - metabolism; Insecticides - analysis; Insecticides - metabolism; kidneys; lindane; liver; Liver - chemistry; Liver - metabolism; Lung - chemistry; Lung - metabolism; Male; men; Middle Aged; polychlorinated biphenyls; Polychlorinated Biphenyls - analysis; Polychlorinated Biphenyls - metabolism; Risk Assessment; Sex Factors; women; 약학
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/BF02977350

In order to investigate the residual amounts of organochlorines and polychlorinated biphenyls (PCBs) in Korean human tissues (blood, adipose tissue, liver, kidney cortex, and lung), the samples were collected from the autopsied cadavers of 40 men and 40 women (from teens to seventies of age) α-BHC, β-BHC, γ-BHC, σ-BHC,p,p′-DDT,p,p′-DDD,p,p′-DDE, endrin, dieldein, aldrin, and 7 marker PCBs (28, 52, 101, 118, 138, 153, and 180) were determined in human tissues. The levels of organochlorines and PCB congeners indicated that they have been widely distributed in Korean human body. Positive correlations in terms of age were observed for the following cases:p,p′-DDE,p,p′-DDT, θ-DDT, PCB 118, PCB 138, PCB 153, and θ-PCB in the adipose tissue, andp,p′-DDE in the lung. Concentration of these compounds showed a significant age-related increase. Accumulation of these compounds in aged people revealed that these compounds were more slowly eliminated in our environment and risk assessment was necessary for further proper action. Significant differences in the levels of PCBs between genders were found for PCB 118 in the adipose tissue and PCB 138 in the liver. Positive correlation coefficients between tissues were detected withp,p′-DDE and β-BHC.