Drug release from xyloglucan beads coated with Eudragit for oral drug delivery

Xyloglucan (XG), which exhibits thermal sol to gel transition, non-toxicity, and low gelation concentration, is of interest in the development of sustained release carriers for drug delivery. Drug-loaded XG beads were prepared by extruding dropwise a dispersion of indomethacin in aqueous XG solution...

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Bibliographic Details
Published in:Archives of pharmacal research 2005, 28(6), , pp.736-742
Main Authors: Yoo, Mi Kyong, Choi, Hoo Kyun, Kim, Tae Hee, Choi, Yun Jaie, Akaike, Toshihiro, Shirakawa, Mayumi, Cho, Chong Su
Format: Article
Language:English
Subjects:
Administration, Oral
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Delayed-Action Preparations
Drug Carriers
Gels
Glucans - chemistry
Hydrogen-Ion Concentration
Indomethacin - administration & dosage
Microscopy, Electron, Scanning
Microspheres
Particle Size
Polymethacrylic Acids - chemistry
Time Factors
Xylans - chemistry
약학
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Summary:Xyloglucan (XG), which exhibits thermal sol to gel transition, non-toxicity, and low gelation concentration, is of interest in the development of sustained release carriers for drug delivery. Drug-loaded XG beads were prepared by extruding dropwise a dispersion of indomethacin in aqueous XG solution (2 wt.-%) through a syringe into corn oil. Enteric coating of XG bead was performed using Eudragit L 100 to improve the stability of XG bead in gastrointestinal (GI) track and to achieve gastroresistant drug release. Release behavior of indomethacin from XG beads in vitro was investigated as a function of loading content of drug, pH of release medium, and concentration of coating agent. Adhesive force of XG was also measured using the tensile test. Uniform-sized spherical beads with particle diameters ranging from 692 +/- 30 to 819 +/- 50 microm were obtained. The effect of drug content on the release of indomethacin from XG beads depended on the medium pH. Release of indomethacin from XG beads was retarded by coating with Eudragit and increased rapidly with the change in medium pH from 1.2 to 7.4. Adhesive force of XG was stronger than that of Carbopol 943 P, a well-known commercial mucoadhesive polymer, in wet state. Results indicate the enteric-coated XG beads may be suitable as a carrier for oral drug delivery of irritant drug in the stomach.
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02969366