Immunobioloical Activity of a New Benzyl Benzoate from the Aerial Parts of Solidago virga-aurea var. gigantea

The chromatographic separation of the hexane soluble fraction of the methanol extract of the aerial parts of Solidago virga-aurea var. gigantea MIQ. (Compositae) led to the isolation of a new benzylbenzoate (1) together with four known benzylbenzoates (2~5). Their structures were determined as 2-met...

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Bibliographic Details
Published in:Archives of pharmacal research 2005, 28(1), , pp.49-54
Main Authors: Sang Zin Choi, 이강노, Sang Un Choi, Seong Yun Bae, 표석능
Format: Article
Language:English
Subjects:
약학
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Summary:The chromatographic separation of the hexane soluble fraction of the methanol extract of the aerial parts of Solidago virga-aurea var. gigantea MIQ. (Compositae) led to the isolation of a new benzylbenzoate (1) together with four known benzylbenzoates (2~5). Their structures were determined as 2-methoxybenzyl-2-hydroxybenzoate (1), benzyl-2-hydroxy-6-methoxybenzoate (2), 2-methoxybenzyl-2,6- dimethoxybenzoate (3), 2-methoxybenzyl-2-methoxy-6- hydroxybenzoate (4), and benzyl-2,6-dimethoxybenzoate (5). Their structures were established by spectroscopic methods. Biological effects of compounds, 1 and 2, were investigated in vitro using mouse peritoneal macrophages. The benzylbenzoates (1 and 2) could serve as immunotherapeutic agents by stimulating macrophage functions, with potential use in the treatment of infectious diseases. KCI Citation Count: 15
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02975135