Brain 18F-FDG, 18F-Florbetaben PET/CT, 123I-FP-CIT SPECT and Cardiac 123I-MIBG Imaging for Diagnosis of a "Cerebral Type" of Lewy Body Disease

A 67-year-old man was referred for fluctuating neuropsychiatric symptoms, featuring depression, delirious episodes, recurrent visual hallucinations and catatonic syndrome associated with cognitive decline. No parkinsonism was found clinically even under neuroleptic treatment. 18 F-FDG PET/CT showed...

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Published in:Nuclear medicine and molecular imaging 2016, 50(3), , pp.258-260
Main Authors: Van Der Gucht, Axel, Cleret de Langavant, Laurent, Bélissant, Ophélie, Rabu, Corentin, Cottereau, Anne-Ségolène, Evangelista, Eva, Chalaye, Julia, Bonnot-Lours, Sophie, Fénelon, Gilles, Itti, Emmanuel
Format: Article
Language:English
Subjects:
Cardiology
Case Report
Imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Orthopedics
Radiology
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Summary:A 67-year-old man was referred for fluctuating neuropsychiatric symptoms, featuring depression, delirious episodes, recurrent visual hallucinations and catatonic syndrome associated with cognitive decline. No parkinsonism was found clinically even under neuroleptic treatment. 18 F-FDG PET/CT showed hypometabolism in the posterior associative cortex including the occipital cortex, suggesting Lewy body dementia, but 123 I-FP-CIT SPECT was normal and cardiac 123 I-MIBG imaging showed no signs of sympathetic denervation. Alzheimer's disease was excluded by a normal 18 F-florbetaben PET/CT. This report suggests a rare case of α-synucleinopathy without brainstem involvement, referred to as "cerebral type" of Lewy body disease.
ISSN:1869-3474
1869-3482
DOI:10.1007/s13139-016-0394-0