Characteristics of function-anatomy mismatch in patients with coronary artery disease

Coronary lesions with mismatched functional and anatomical significance are not uncommon. We assessed the accuracy and predictors of mismatch between fractional flow reserve (FFR) and quantitative coronary angiography (QCA) analyses in patients with coronary lesions. A total of 643 lesions with pre-...

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Published in:Korean circulation journal 2014, 44(6), , pp.394-399
Main Authors: Cho, Hyun-Ok, Nam, Chang-Wook, Cho, Yun-Kyeong, Yoon, Hyuck-Jun, Park, Hyoung-Seob, Kim, Hyungseop, Chung, In-Sung, Doh, Joon-Hyung, Koo, Bon-Kwon, Hyun, Dae-Woo, Hur, Seung-Ho, Kim, Yoon-Nyun, Kim, Kwon-Bae
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container_title Korean circulation journal
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creator Cho, Hyun-Ok
Nam, Chang-Wook
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Kim, Kwon-Bae
description Coronary lesions with mismatched functional and anatomical significance are not uncommon. We assessed the accuracy and predictors of mismatch between fractional flow reserve (FFR) and quantitative coronary angiography (QCA) analyses in patients with coronary lesions. A total of 643 lesions with pre-interventional FFR and QCA measurements were consecutively enrolled and divided into four groups using FFR ≤0.80 and percent diameter stenosis (%DS) ≥50% as cutoffs for functional and anatomical significance, respectively. Accordingly, FFR >0.80 and DS ≥50%, and FFR ≤0.80 and DS
doi_str_mv 10.4070/kcj.2014.44.6.394
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We assessed the accuracy and predictors of mismatch between fractional flow reserve (FFR) and quantitative coronary angiography (QCA) analyses in patients with coronary lesions. A total of 643 lesions with pre-interventional FFR and QCA measurements were consecutively enrolled and divided into four groups using FFR ≤0.80 and percent diameter stenosis (%DS) ≥50% as cutoffs for functional and anatomical significance, respectively. Accordingly, FFR &gt;0.80 and DS ≥50%, and FFR ≤0.80 and DS &lt;50% defined false-positive (FP) and false-negative (FN) lesions, respectively. Overall, 40.4% (260/643) of the lesions were mismatched, and 51.7% (218/414) and 18.3% (42/229) were FP and FN lesions, respectively. In a multivariate analysis, independent predictors of FP were non-left anterior descending artery location {odds ratio (OR), 0.36; 95% confidence interval (CI), 0.28-0.56; p&lt;0.001}, shorter lesion length (OR, 0.96; 95% CI, 0.95-0.98; p&lt;0.001), multi-vessel disease (OR, 0.47; 95% CI, 0.30-0.75; p=0.001), and larger minimal lumen diameter by QCA (OR, 2.88; 95% CI,1.65-5.00; p&lt;0.001). Independent predictors of FN were multi-vessel disease (OR, 1.82; 95% CI, 1.24-5.27; p=0.048), aging (OR, 0.96; 95% CI, 0.93-0.99; p=0.034), smoking (OR, 0.36; 95% CI, 0.14-0.93; p=0.034), and smaller reference vessel diameter by QCA (OR, 0.30; 95% CI, 0.10-0.87; p=0.026). 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내과학
title Characteristics of function-anatomy mismatch in patients with coronary artery disease
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