Fenofibrate reduces C-reactive protein levels in hypertriglyceridemic patients with high risks for cardiovascular diseases

The effects of fenofibrate on C-reactive protein (CRP) are under debate. We investigated the effect of fenofibrate on CRP levels and the variables determining changes. This case-control study enrolled 280 hypertriglyceridemic patients who were managed either with 200 mg of fenofibrate (Fenofibrate g...

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Bibliographic Details
Published in:Korean circulation journal 2012, 42(11), , pp.741-746
Main Authors: Min, Yun Joo, Choi, Young Hwan, Hyeon, Cheol Won, Cho, Jun Hwan, Kim, Kyung Joon, Kwon, Jee Eun, Kim, Eun Young, Lee, Wang-Soo, Lee, Kwang Je, Kim, Sang-Wook, Kim, Tae Ho, Kim, Chee Jeong
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Language:English
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내과학
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Summary:The effects of fenofibrate on C-reactive protein (CRP) are under debate. We investigated the effect of fenofibrate on CRP levels and the variables determining changes. This case-control study enrolled 280 hypertriglyceridemic patients who were managed either with 200 mg of fenofibrate (Fenofibrate group, n=140) or with standard treatment (comparison group, n=140). CRP levels were measured before and after management for 2 months. CRP levels decreased in both the fenofibrate (p=0.003) and comparison (p=0.048) groups. Changes in CRP levels were not significantly different between the two groups (p=0.27) and were negatively associated with baseline CRP levels (r=-0.47, p
ISSN:1738-5520
1738-5555
DOI:10.4070/kcj.2012.42.11.741