APTT에서 경계치에 속한 정상 성인의 혈액응고인자 활성도 분석

• Published in: Korean journal of clinical laboratory science 2015, 47(4), , pp.237-242
• Main Authors: 권의훈, Eui Hoon Kwon, 구본경, Bon Kyung Koo, 방성환, Sung Hwan Bang, 김희진, Hee Jin Kim, 조영국, Young Kuk Cho
• Format: Article
• Language: Korean
• Subjects: ABO blood type; Activated partial thromboplastin time; Coagulation factor activity; Reference range; 기타자연과학
• ISSN: 1738-3544; 2288-1662

aPTT 참고치의 정상범위 내에서 하한 측 10% (29.1∼30.9 sec)와 상한 측 10% (38.0∼41.9 sec)에 포함된 정상성인의 혈액응고 인자 활성도를 분석하여 하한 측과 상한 측간에 혈액응고인자의 종류와 각각의 활성도가 성별, 연령 및 ABO 혈액형 등에 통계학적으로 유의한 차이를 보이는지 알아보고자 하였다. 성별에 따른 혈액 응고인자들의 활성도 차이를 분석한 결과 하한 측에서 IX (p=0.0088)만 남성이 여성보다 높았으며, 상한 측에서 IX (p＜0.0001)와 X (p=0.0013)은 남성이 여성보다 높았다. 연령군간 혈액응고인자들의 활성도 차이 검정은 하한 측에서 VIII (p＜0.0001), IX (p=0.0050)는 60세 이상이 60세 미만보다 높았으며, XII (p=0.0285)는 60세이상보다 60세 미만이 높았다. 상한 측에서 V (p=0.0219), VIII (p=0.0005), IX (p=0.0014)는 60세 이상이 60세 미만보다 높았다. O형과 non-O형의 혈액형 구분에 의한 혈액응고인자들의 활성도차이는 VIII (p＜0.001)은 양쪽 그룹에서 non-O형이 O형보다 높았으며, XII (p=0.016)는 상한 측에서 non-O형이 O형보다 낮았다. The coagulation factor activity compared two groups of the lower 10% (29.1∼30.9 sec) and the upper 10% (38.0∼41.9 sec) of the normal reference range of aPTT. The aim of this study was to investigate the influence of sex, age, and ABO blood type on coagulation factor activity. There was significant difference in the activity of the coagulation factor assay based on age. The VIII (p＜0.0001) and IX (p=0.0050) in the lower group of samples from those over sixty years of age is higher than from those under sixty. In contrast, XII (p=0.0285) for samples over sixty was lower than for samples under sixty. While in the upper group V (p=0.0219), VIII (p=0.0005), and IX (p=0.0014) for samples from the over sixty group was higher than those under sixty. In the case of activity of coagulation factor between O and non-O blood type, VIII (p＜0.001) activity of the non-O blood type was higher than that of the O blood type in the both groups. The XII (p=0.016) activity of non-O blood type was lower than that of O blood type in the upper group. According to the multiple logistic regression analysis, when other variables are under the same conditions between lower and upper groups, there is a strong possibility for the lower group when activity of V (p=0.001), VIII (p＜0.001), X (p＜0.001) and XII (p＜0.001) is increased. Furthermore, there is also a strong possibility of upper group when activity of II (p=0.004) and IX (p=0.012) is increased. However, no significant difference in between sex, age and XI was observed.