Neuroprotective effect of Reseda luteola L. extract in a mouse neuronal cell model

Aqueous extracts of Reseda luteola L. used as a dyeing agent for centuries have antioxidant activities. The neuroprotective effect of aqueous herb extracts were investigated against glutamate-induced reactive oxygen species (ROS) insult using mouse hippocampal HT22 and cortical neural cells. Aqueous...

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Bibliographic Details
Published in:Food science and biotechnology 2015, 24(1), , pp.333-339
Main Authors: Kim, Seong Soon, Seo, Ji Yeon, Lim, Soon Sung, Suh, Hwa Jin, Kim, Lione, Kim, Jong-Sang
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Food Science
Nutrition
Research Article
Reseda
식품과학
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Summary:Aqueous extracts of Reseda luteola L. used as a dyeing agent for centuries have antioxidant activities. The neuroprotective effect of aqueous herb extracts were investigated against glutamate-induced reactive oxygen species (ROS) insult using mouse hippocampal HT22 and cortical neural cells. Aqueous extracts and the hexane fraction of R. luteola L. effectively attenuated the cytotoxicity of glutamate (5 mM) in both HT22 and primary neural cells derived from the mouse cortex. The neuroprotective effect was attributable to unidentified components and luteolin, which is known as a biologically active constituent. Aqueous extracts of R. luteola L. deserve further study for identification of active components and development of food colorants with health benefits.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-015-0044-9