Effects of blue mussel (ME) water extracts on pentobarbital-induced sleep and the sleep architecture in mice

Blue mussel ( Mytilus edulis ) is a popular shellfish that is used widely in the daily diet. It has antioxidant, antimicrobial, and anticoagulant properties. The hypnotic effects of blue mussel (ME) water extracts in a mouse model were investigated. Oral administration of ME water extracts produced...

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Bibliographic Details
Published in:Food science and biotechnology 2015, 24(1), , pp.295-300
Main Authors: Ta, Quang Van, Yoon, Minseok, Yang, Hyejin, Kim, Jiyoung, Cho, Suengmok, Kang, Kyong-Hwa, Kim, Young-Sang, Park, Sun-Joo, Kim, Se-Kwon
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Food Science
Mytilus edulis
Nutrition
Research Article
식품과학
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Summary:Blue mussel ( Mytilus edulis ) is a popular shellfish that is used widely in the daily diet. It has antioxidant, antimicrobial, and anticoagulant properties. The hypnotic effects of blue mussel (ME) water extracts in a mouse model were investigated. Oral administration of ME water extracts produced a dose-dependent decrease in sleep latency and an increase in sleep duration in pentobarbital-treated mice. At concentrations of 500 and 1,000 mg/kg, the extracts also increased the sleep onset rate (90 and 90%, respectively) and sleep duration (46.3±4.9 and 58.3±2.0 min, respectively) in sub-hypnotic dosage testing. Electroencephalograms (EEG) and electromyograms (EMG) showed that ME water extracts reduced sleep latency and induced non-rapid eye movement sleep (NREMS) while maintaining rapid eye movement sleep (REMS). ME water extracts did not affect the EEG power density. ME water extract-induced sleep is similar to physiological sleep in a mouse model.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-015-0039-6