Anti-adipogenic effects in 3T3-L1 cells of acetone extracts and fractions from Styrax japonica fruit

Reduction in reactive oxygen species (ROS) production facilitated by Styrax japonica (SJ) extracts and fractions for inhibition of obesity development through inhibition of adipogenesis was investigated. Treatment of cells with SJ extracts and fractions did not result in changes in cell viability. S...

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Bibliographic Details
Published in:Food science and biotechnology 2015, 24(4), , pp.1513-1521
Main Authors: Kim, Jin Kyu, Nam, Hajin, Kim, Yoo Yeon, Jung, Harry, Choi, Yoon Soo, Oh, Joa Sub, Chun, Su Kyoung, Suh, Jun Gyo
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Food Science
Nutrition
Research Article
Styrax
식품과학
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Summary:Reduction in reactive oxygen species (ROS) production facilitated by Styrax japonica (SJ) extracts and fractions for inhibition of obesity development through inhibition of adipogenesis was investigated. Treatment of cells with SJ extracts and fractions did not result in changes in cell viability. SJ extracts and fractions inhibited lipid accumulation in a dose-dependent manner during adipogenesis. Expressions of PPARγ and C/EBPα, key adipogenic markers, were decreased in cells treated with SJ extracts and fractions. Inhibitory effects of SJ extracts and fractions were the most powerful in the early stages of differentiation (days 0-2). Intracellular ROS production was decreased in cells treated with SJ extracts and fractions. SJ extracts and fractions can inhibit adipogenesis via reduced ROS levels, which involves down-regulation of adipogenic transcription factors.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-015-0195-8