Inhibitory effect of the ethyl acetate fraction from astringent persimmon on H2O2-induced oxidative stress in HepG2 cells

Persimmon cv. Sangjudungsi ( Diospyros kaki Thunb.) is a major astringent cultivar in Korea. A phenolic extract of cv. Sangjudungsi was obtained using acetone with homogenization, then sequentially fractionated into n -hexane, chloroform, ethyl acetate, n -butanol, and water fractions. These 5 fract...

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Bibliographic Details
Published in:Food science and biotechnology 2014, 23(4), , pp.1247-1252
Main Authors: Lee, Moon Seok, Lee, In Il, Kim, Yongeun, Kim, Young Jun, Heo, Ho Jin, Kim, Dae-Ok
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Food Science
Nutrition
Research Article
식품과학
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Summary:Persimmon cv. Sangjudungsi ( Diospyros kaki Thunb.) is a major astringent cultivar in Korea. A phenolic extract of cv. Sangjudungsi was obtained using acetone with homogenization, then sequentially fractionated into n -hexane, chloroform, ethyl acetate, n -butanol, and water fractions. These 5 fractions were used to evaluate levels of total phenolics and total flavonoids, and the antioxidant capacities, and to investigate whether the fractions protected human hepatoma HepG2 cells from deleterious oxidative stress. The ethyl acetate fraction had the highest levels of total phenolics and total flavonoids, and the greatest antioxidant capacity. Under oxidative stress caused by H 2 O 2 , the ethyl acetate fraction at non-toxic concentrations significantly ( p
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-014-0171-8