Antioxidant activity and hepatoprotective effect of Schizandra chinensis Baill. Extracts containing active components in alcohol-induced HepG2 cells

The antioxidant activities and hepatoprotective effects of Schizandra chinensis Baill. extracts (SCE) were evaluated. The contents of the active components schisandrin, schisandrin C, gomisin A, and gomisin N in SCE were 8.802±1.390, 1.011±0.203, 0.954±0.191, and 3.351±0.829 mg/g, respectively. The...

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Published in:Food science and biotechnology 2014, 23(5), , pp.1615-1621
Main Authors: Sung, Misun, Park, Sung Sun, Kim, Sung-Soo, Han, Chan-Kyu, Hur, Jung-Mu
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Food Science
Nutrition
Research Article
식품과학
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Summary:The antioxidant activities and hepatoprotective effects of Schizandra chinensis Baill. extracts (SCE) were evaluated. The contents of the active components schisandrin, schisandrin C, gomisin A, and gomisin N in SCE were 8.802±1.390, 1.011±0.203, 0.954±0.191, and 3.351±0.829 mg/g, respectively. The antioxidant activity of SCE was measured based on the DPPH free radical scavenging activity and the superoxide dismutase (SOD)-like activity. The IC 50 values for the DPPH radical scavenging activity and SOD-like activity were 18.1 and 44.2mg/mL, respectively. The protective effect of SCE against alcohol-induced oxidative injury in HepG2 cells was investigated. Cells pretreated with SCE (100–400 μg/mL) showed an increased resistance to oxidative stress in a dose-dependent manner. Expressions of Bcl-2 and pro-caspase-3 proteins were induced by SCE in HepG2 cells. SCE can be useful for management of antioxidant and hepatoprotective effects.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-014-0220-3