Isolation of xanthones from adventitious roots of St. John’s Wort (Hypericum perforatum L.) and their antioxidant and cytotoxic activities

In this phytochemical study, 5 xanthones, 1,3,5,6-tetrahydroxyxanthone [1] , 1,5,6-trihydroxy-3-methoxyxanthone [2] , ferrxanthone [3] , brasilixanthone B [4] , and neolancerin [5] were isolated from adventitious roots of St. John’s wort ( Hypericum perforatum L.). Compound 1–5 were evaluated for an...

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Bibliographic Details
Published in:Food science and biotechnology 2013, 22(4), , pp.945-949
Main Authors: Li, Wei, Sun, Ya Nan, Yan, Xi Tao, Yang, Seo Young, Choi, Chun Whan, Hyun, Jin Won, Kang, Hee Kyoung, Paek, Kee Yoeup, Kim, Young Ho
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Food Science
Nutrition
Research Note
식품과학
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Summary:In this phytochemical study, 5 xanthones, 1,3,5,6-tetrahydroxyxanthone [1] , 1,5,6-trihydroxy-3-methoxyxanthone [2] , ferrxanthone [3] , brasilixanthone B [4] , and neolancerin [5] were isolated from adventitious roots of St. John’s wort ( Hypericum perforatum L.). Compound 1–5 were evaluated for antioxidant activities using the intracellular reactive oxygen species (ROS) radical scavenging 2′,7′-dichlorfluorescein-diacetate (DCFDA) assay and for cytotoxic activity against the HL-60 human promyelocytic leukemia cells. Among them, compound 1–4 exhibited scavenging activity with inhibition values of 27.4–33.2% at 10 μM; compound 1, 2, and 4 reduced the viability of HL-60 cells significantly, with IC 50 values of 31.5, 28.9, and 27.7 μM, respectively.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-013-0168-8