Chaga mushroom (Inonotus obliquus) grown on germinated brown rice suppresses inflammation associated with colitis in mice

The aim of this study was to evaluate the antiinflammatory activity of ethanol extracts from chaga mushroom (Inonotus obliquus, IOE) grown on germinated brown rice. A total of 35 male BALB/c mice were divided into 5 treatment groups and given a commercial diet (A), IOE administration (B), dextran so...

Full description

Saved in:
Bibliographic Details
Published in:Food science and biotechnology 2012, 21(5), , pp.1235-1241
Main Authors: Debnath, Trishna, Konkuk University, Chungju, Republic of Korea, Hasnat, Md. Abul, Konkuk University, Chungju, Republic of Korea, Pervin, Mehnaz, Konkuk University, Chungju, Republic of Korea, Lee, S.Y., Konkuk University, Chungju, Republic of Korea, Park, S.R., Konkuk University, Chungju, Republic of Korea, Kim, D.H., Konkuk University, Chungju, Republic of Korea, Kweon, H.J., Konkuk University, Chungju, Republic of Korea, Kim, J.M., Konkuk University, Chungju Hospital, Chungju, Republic of Korea, Lim, B.O., Konkuk University, Chungju, Republic of Korea
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
COLITE
COLITIS
Crohn's disease
Food Science
inflammatory bowel disease
Nutrition
Research Article
ulcerative colitis
식품과학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to evaluate the antiinflammatory activity of ethanol extracts from chaga mushroom (Inonotus obliquus, IOE) grown on germinated brown rice. A total of 35 male BALB/c mice were divided into 5 treatment groups and given a commercial diet (A), IOE administration (B), dextran sodium sulfate (DSS) treatment to induce colitis (C), IOE administration+DSS-induced colitis (D), and sulfasalazine administration+ DSS-induced colitis (E). IOE treatment (D) decreased the expression of tumor necrosis factor (TNF)-α, cyclooxygenase (COX)-2, interleukin (IL)-4, interferon (IFN)-γ, signal transducers and activators of transcription (STAT)1, and STAT6 and showed lower levels of immunoglobulin (Ig)E and IgA in the spleen and mesenteric lymph node (MLN) compared to those of the DSS-induced colitis group (C). In addition, IOE suppressed the DSS-induced colonic tissue destruction. Therefore, our data strongly suggests that IOE could be a potent anti-inflammatory agent.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-012-0162-6