Anti-photoaging Effects of 2-Methoxy-5-(2-methyl propyl) Pyrazine Isolated from Peach (Prunus persica (L.) Batsch)

In this study, antioxidant and anti-photoaging activities of 2-methoxy-5-(2-methyl propyl) pyrazine (MMPP) isolated from peach (Prunus persica (L.) Batsch) were investigated in terms of matrix metalloproteinase (MMP)-1 and type-1 procollagen expression in ultraviolet (UV)-irradiated human skin fibro...

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Published in:Food science and biotechnology 2010, 19(6), , pp.1667-1671
Main Authors: Han, Sung-Hwa, Park, Kwang-Kyun, Chung, Won-Yoon, Lee, Sang-Kook, Kim, Jae-Kyung, Hwang, Jae-Kwan
Format: Article
Language:Korean
Subjects:
식품과학
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Summary:In this study, antioxidant and anti-photoaging activities of 2-methoxy-5-(2-methyl propyl) pyrazine (MMPP) isolated from peach (Prunus persica (L.) Batsch) were investigated in terms of matrix metalloproteinase (MMP)-1 and type-1 procollagen expression in ultraviolet (UV)-irradiated human skin fibroblasts. MMPP was obtained from the butanol fraction of a 95% ethanol extract of peach. The antioxidant and anti-photoaging activity of MMPP were assessed by 1,1-diphenyl-2-picrylhydrazy (DPPH), Western blot, and reverse trans-cription-polymerase chain reaction (RT-PCR) analyses. MMPP displayed radical scavenging activity, suppressed MMP-1 expression, and increased type-1 procollagen expression. These results support the use of MMPP from peach as an antiphotoaging compound.
ISSN:1226-7708
2092-6456