Protective Effects of Loquat (Eriobotrya japonica) Leaves against Ethanol-induced Toxicity in HepG2 Cells Transfected with CYP2E1

Hepatoprotective effects of loquat (Eriobotrya japonica) leaves were investigated in HepG2 cells over-expressing CYP2E1. When compared to cells treated with 200 mM ethanol alone, a concentration-dependent increase in cell viability was observed in the cells pretreated with 40 and 80 ㎍/mL of 5% ethan...

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Published in:Food science and biotechnology 2010, 19(4), , pp.1093-1096
Main Authors: Bae, D.H., Chonnam National University, Gwangju, Republic of Korea, You, Y.H., Chonnam National University, Gwangju, Republic of Korea, Yoon, H.G., Yonsei University, Seoul, Republic of Korea, Kim, K.M., Korea Bio Polytechnic College, Nonsan, Republic of Korea, Lee, Y.H., The University of Suwon, Suwon, Republic of Korea, Kim, Y.J., Chonnam National University, Gwangju, Republic of Korea, Baek, H.Y., Korea INS Pharm Research Institute, Hwasun, Republic of Korea, Kim, S.O., Jeonnam Institute of Natural Resources Research, Jangheung, Republic of Korea, Lee, J.M., Kyung Hee University, Yongin, Republic of Korea, Jun, W.J., Chonnam National University, Gwangju, Republic of Korea
Format: Article
Language:English
Subjects:
antioxidation
Chemistry
Chemistry and Materials Science
Eriobotrya japonica
ESTRES OXIDATIVO
Food Science
hepatoprotection
LOQUATS
NEFLE (ERIOBOTRYA)
NISPERO (ERIOBOTRYA)
Nutrition
OXIDATIVE STRESS
Research Note
STRESS OXYDATIF
식품과학
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Summary:Hepatoprotective effects of loquat (Eriobotrya japonica) leaves were investigated in HepG2 cells over-expressing CYP2E1. When compared to cells treated with 200 mM ethanol alone, a concentration-dependent increase in cell viability was observed in the cells pretreated with 40 and 80 ㎍/mL of 5% ethanol extract (EJE) of loquat leaves (23 and 36%, respectively). Also, pretreatment with EJE lead to a decrease in intracellular reactive oxygen species formation and an increase in hepatic antioxidant activity. These results suggest that EJE attenuates oxidative stress by improving antioxidative potentials, which contribute to this herb's protective profile against ethanol-induced toxicity in vitro.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-010-0154-3