Comparison of clonidine and midazolam premedication before endoscopic sinus surgery: results of clinical trial

• Published in: Clinical and experimental otorhinolaryngology 2014, 7(4), , pp.307-311
• Main Authors: Wawrzyniak, Katarzyna, Kusza, Krzysztof, Cywinski, Jacek B
• Format: Article
• Language: English
• Subjects: Anesthesia; Clonidine; Minimally invasive; Original; Premedication; Surgical procedures; 이비인후과학
• ISSN: 1976-8710; 2005-0720
• DOI: 10.3342/ceo.2014.7.4.307

Premedication with clonidine has been found to reduce the bleeding during endoscopic sinus surgery (ESS), therefore lowering the risk of surgical complications. Premedication is an essential part of pre-surgical care and can potentially affect magnitude of systemic stress response to a surgical procedure. The aim of this study was to compare the efficacy of premedication with clonidine and midazolam in patients undergoing sinus surgery. Forty-four patients undergoing ESS for chronic sinusitis and polyp removal were enrolled and randomly assigned to receive either oral clonidine or midazolam as a premedication before receiving propofol/remifentanil total intravenous anesthesia. The effect of this premedication choice on anesthetic requirements, intraoperative hemodynamic profile, preoperative anxiety and sedation as well as postoperative pain and shivering were examined in each premedication group. Total intraoperative remifentanil requirement was lower in the clonidine group as compared to the midazolam group 503.2±147.0 µg vs. 784.5±283.8 µg, respectively (P