Inhibitory action of purified hydroxytyrosol from stored olive mill waste on intestinal disaccharidases and lipase activities and pancreatic toxicity in diabetic rats

This study was established that after 3 months storage, olive mill waste (OMW) was enriched with hydroxytyrosol (HT) (2,652 mg/L) and contained only phenolic monomers. It also showed that HT supplementation to surviving diabetic rats decreases considerably intestinal maltase, lactase, sucrose, and l...

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Published in:Food science and biotechnology 2010, 19(2), , pp.439-447
Main Authors: Hamden, Khaled, Faculty of Science of Sfax, Sfax, Tunisia, Allouche, Noureddine, Faculty of Science of Sfax, Sfax, Tunisia, Jouadi, Bessam, Centre of Biotechnology of Sfax, Sfax, Tunisia, El-Fazaa, Saloua, Faculty of Science of El-Manar I, Tunis, Tunisia, Gharbi, Najoua, Faculty of Science of El-Manar I, Tunis, Tunisia, Carreau, Serge, University of Caen-Basse Normandie, USC INRA, CHU-Caen, France, Damak, Mohamed, Faculty of Science of Sfax, Sfax, Tunisia, Elfeki, Abdelfattah, Faculty of Science of Sfax, Sfax, Tunisia
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Computer Science
DIABETE
DIABETES
disaccharidase
Food Science
hydroxytyrosol
intestinal
Life Sciences
lipase
Nutrition
Olea
olive mill waste
Research Article
식품과학
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Summary:This study was established that after 3 months storage, olive mill waste (OMW) was enriched with hydroxytyrosol (HT) (2,652 mg/L) and contained only phenolic monomers. It also showed that HT supplementation to surviving diabetic rats decreases considerably intestinal maltase, lactase, sucrose, and lipase activities by 49, 31, 42, and 40%, respectively. In addition, HT enhanced the superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities by 330, 170, and 301%, respectively and reduced gluthation (GSH) level by 79% in pancreas compared to diabetic rats. Moreover, a significant decrease in the thiobarbituric acid reactive substances (TBARs) level and lactate dehydrogenase (LDH) activity in diabetic rats pancreas by 34 and 49% respectively after administration of HT. In addition, HT improved plasma triglyceride and cholesterol levels in diabetic rats by lowering low density lipoprotein (LDL)-cholesterol and triglycerides (TG) by 27 and 53%, respectively and increasing high density lipoprotein (HDL)-cholesterol content by 72%. These properties of HT are interesting regarding its use as therapeutic agent in biotechnological applications, especially in developing anti-diabetic and hypocholesterolemic drugs.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-010-0062-6