Combined phototherapy in anti-cancer treatment: therapeutics design and perspectives

Photodynamic (PDT) and photothermal (PTT) therapy are proven effective strategies for the treatment of cancer. PDT, a photochemistry-based therapy, utilises light energy based photosensitiser for the production of cytotoxic species via electron transfer to biological substrates and potential excitat...

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Bibliographic Details
Published in:Journal of pharmaceutical investigation 2016, 46(6), , pp.505-517
Main Authors: Tran, Tuan Hiep, Thapa, Raj Kumar, Nguyen, Hanh Thuy, Pham, Tung Thanh, Ramasamy, Thiruganesh, Kim, Dong Shik, Yong, Chul Soon, Kim, Jong Oh, Choi, Han-Gon
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Review
약학
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Summary:Photodynamic (PDT) and photothermal (PTT) therapy are proven effective strategies for the treatment of cancer. PDT, a photochemistry-based therapy, utilises light energy based photosensitiser for the production of cytotoxic species via electron transfer to biological substrates and potential excitation or energy transfer to molecular oxygen. On the other hand, PTT utilises substances that can convert light energy into heat for efficient tumour ablation. This review provides an insight into the current research investigations of different nanocarriers utilising the synergistic effects of PTT and PDT for anticancer therapy.
ISSN:2093-5552
2093-6214
DOI:10.1007/s40005-016-0272-x