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Antioxidant and cognitive-enhancing activities of Arctium lappa L. roots in Aβ1-42-induced mouse model
Many studies have shown that oxidative stress induced by hydrogen peroxide can lead to neuronal cell death. In this study, protective effects of the ethanol extract of A. lappa L. roots against oxidative stress in PC12 cells were measured by 2′, 7′-dichlorofluorescein diacetate and 3-(4,5-dimethylth...
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| Published in: | Applied biological chemistry 2016, 59(4), , pp.553-565 |
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| container_end_page | 565 |
| container_issue | 4 |
| container_start_page | 553 |
| container_title | Applied biological chemistry |
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| creator | Kwon, Yoon Kyung Choi, Soo Jung Kim, Cho Rong Kim, Jae Kyeom Kim, Youn-Jung Choi, Jong Hun Song, Sang-Wook Kim, Chang-Ju Park, Gwi Gun Park, Cheung-Seog Shin, Dong-Hoon |
| description | Many studies have shown that oxidative stress induced by hydrogen peroxide can lead to neuronal cell death. In this study, protective effects of the ethanol extract of
A. lappa
L. roots against oxidative stress in PC12 cells were measured by 2′, 7′-dichlorofluorescein diacetate and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Oxidative stress contributes to the memory deficits induced by Beta-amyloid
1-42
in mice. Treatment with the ethanol extract of
A. lappa
L. roots improved working and reference memory in mice in the Y-maze and passive avoidance tests. To detect the lipid peroxidation levels, malondialdehyde was measured. To purify the bioactive compound, active fractions and components of
A. lappa
L. roots were isolated by partitioning, open column chromatography, TLC, high-performance liquid chromatography, electron ionization mass spectrometry, and
1
H/
13
C-nuclear magnetic resonance. We identified the bioactive compound as quinic acid, which is a powerful antioxidant agent. Ultimately, the roots of
A. lappa
L. may become available as an antioxidant food for Alzheimer’s disease patients and those with other oxidative stress-induced disorders. |
| doi_str_mv | 10.1007/s13765-016-0195-2 |
| format | article |
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A. lappa
L. roots against oxidative stress in PC12 cells were measured by 2′, 7′-dichlorofluorescein diacetate and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Oxidative stress contributes to the memory deficits induced by Beta-amyloid
1-42
in mice. Treatment with the ethanol extract of
A. lappa
L. roots improved working and reference memory in mice in the Y-maze and passive avoidance tests. To detect the lipid peroxidation levels, malondialdehyde was measured. To purify the bioactive compound, active fractions and components of
A. lappa
L. roots were isolated by partitioning, open column chromatography, TLC, high-performance liquid chromatography, electron ionization mass spectrometry, and
1
H/
13
C-nuclear magnetic resonance. We identified the bioactive compound as quinic acid, which is a powerful antioxidant agent. Ultimately, the roots of
A. lappa
L. may become available as an antioxidant food for Alzheimer’s disease patients and those with other oxidative stress-induced disorders.</description><identifier>ISSN: 2468-0834</identifier><identifier>EISSN: 2468-0842</identifier><identifier>DOI: 10.1007/s13765-016-0195-2</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Alzheimer's disease ; Antioxidants ; Applied Microbiology ; Bioactive compounds ; Biological activity ; Biological Techniques ; Bioorganic Chemistry ; Cell death ; Chemistry ; Chemistry and Materials Science ; Chromatography ; Cognitive ability ; Column chromatography ; Ethanol ; High performance liquid chromatography ; Hydrogen peroxide ; Ionization ; Lipid peroxidation ; Lipids ; Liquid chromatography ; Malondialdehyde ; Mass spectrometry ; Mass spectroscopy ; Memory ; Neurodegenerative diseases ; NMR ; Nuclear magnetic resonance ; Oxidation ; Oxidative stress ; Peroxidation ; Pheochromocytoma cells ; Quinic acid ; Roots ; 농학</subject><ispartof>Applied Biological Chemistry, 2016, 59(4), , pp.553-565</ispartof><rights>The Korean Society for Applied Biological Chemistry 2016</rights><rights>The Korean Society for Applied Biological Chemistry 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3082-ff0d55e8b7c628deb3859af926eae595a3e69bd5382326781623ef81a9f053b03</citedby><cites>FETCH-LOGICAL-c3082-ff0d55e8b7c628deb3859af926eae595a3e69bd5382326781623ef81a9f053b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2399164218?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,25731,27901,27902,36989,44566</link.rule.ids><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002158726$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwon, Yoon Kyung</creatorcontrib><creatorcontrib>Choi, Soo Jung</creatorcontrib><creatorcontrib>Kim, Cho Rong</creatorcontrib><creatorcontrib>Kim, Jae Kyeom</creatorcontrib><creatorcontrib>Kim, Youn-Jung</creatorcontrib><creatorcontrib>Choi, Jong Hun</creatorcontrib><creatorcontrib>Song, Sang-Wook</creatorcontrib><creatorcontrib>Kim, Chang-Ju</creatorcontrib><creatorcontrib>Park, Gwi Gun</creatorcontrib><creatorcontrib>Park, Cheung-Seog</creatorcontrib><creatorcontrib>Shin, Dong-Hoon</creatorcontrib><title>Antioxidant and cognitive-enhancing activities of Arctium lappa L. roots in Aβ1-42-induced mouse model</title><title>Applied biological chemistry</title><addtitle>Appl Biol Chem</addtitle><description>Many studies have shown that oxidative stress induced by hydrogen peroxide can lead to neuronal cell death. In this study, protective effects of the ethanol extract of
A. lappa
L. roots against oxidative stress in PC12 cells were measured by 2′, 7′-dichlorofluorescein diacetate and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Oxidative stress contributes to the memory deficits induced by Beta-amyloid
1-42
in mice. Treatment with the ethanol extract of
A. lappa
L. roots improved working and reference memory in mice in the Y-maze and passive avoidance tests. To detect the lipid peroxidation levels, malondialdehyde was measured. To purify the bioactive compound, active fractions and components of
A. lappa
L. roots were isolated by partitioning, open column chromatography, TLC, high-performance liquid chromatography, electron ionization mass spectrometry, and
1
H/
13
C-nuclear magnetic resonance. We identified the bioactive compound as quinic acid, which is a powerful antioxidant agent. Ultimately, the roots of
A. lappa
L. may become available as an antioxidant food for Alzheimer’s disease patients and those with other oxidative stress-induced disorders.</description><subject>Alzheimer's disease</subject><subject>Antioxidants</subject><subject>Applied Microbiology</subject><subject>Bioactive compounds</subject><subject>Biological activity</subject><subject>Biological Techniques</subject><subject>Bioorganic Chemistry</subject><subject>Cell death</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography</subject><subject>Cognitive ability</subject><subject>Column chromatography</subject><subject>Ethanol</subject><subject>High performance liquid chromatography</subject><subject>Hydrogen peroxide</subject><subject>Ionization</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Liquid chromatography</subject><subject>Malondialdehyde</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Memory</subject><subject>Neurodegenerative diseases</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Peroxidation</subject><subject>Pheochromocytoma cells</subject><subject>Quinic acid</subject><subject>Roots</subject><subject>농학</subject><issn>2468-0834</issn><issn>2468-0842</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp1kMtKxDAUhoMoKKMP4C7gykU0lyZNlkW8wYAgug6ZNqmZSzImrehr-SA-k9GKrlycK99_OPwAHBN8RjCuzzNhteAIE1FCcUR3wAGthERYVnT3t2fVPjjKeYlxIaWgnB2AvgmDj6--M2GAJnSwjX3wg3-xyIYnE1ofemjasihLm2F0sEllHDdwbbZbA-dnMMU4ZOgDbD7eCaoo8qEbW9vBTRyzLbmz60Ow58w626OfOgOPV5cPFzdofnd9e9HMUcuwpMg53HFu5aJuBZWdXTDJlXGKCmssV9wwK9Si40xSRkUtiaDMOkmMcpizBWYzcDrdDcnpVet1NP679lGvkm7uH241oTXhihX2ZGK3KT6PNg96GccUynuaMqWIqCiRhSIT1aaYc7JOb5PfmPSmCdZf9uvJfl1M1V_2F_EM0EmTCxt6m_4u_y_6BERRhqw</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Kwon, Yoon Kyung</creator><creator>Choi, Soo Jung</creator><creator>Kim, Cho Rong</creator><creator>Kim, Jae Kyeom</creator><creator>Kim, Youn-Jung</creator><creator>Choi, Jong Hun</creator><creator>Song, Sang-Wook</creator><creator>Kim, Chang-Ju</creator><creator>Park, Gwi Gun</creator><creator>Park, Cheung-Seog</creator><creator>Shin, Dong-Hoon</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><general>한국응용생명화학회</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M0K</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>ACYCR</scope></search><sort><creationdate>20160801</creationdate><title>Antioxidant and cognitive-enhancing activities of Arctium lappa L. roots in Aβ1-42-induced mouse model</title><author>Kwon, Yoon Kyung ; Choi, Soo Jung ; Kim, Cho Rong ; Kim, Jae Kyeom ; Kim, Youn-Jung ; Choi, Jong Hun ; Song, Sang-Wook ; Kim, Chang-Ju ; Park, Gwi Gun ; Park, Cheung-Seog ; Shin, Dong-Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3082-ff0d55e8b7c628deb3859af926eae595a3e69bd5382326781623ef81a9f053b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alzheimer's disease</topic><topic>Antioxidants</topic><topic>Applied Microbiology</topic><topic>Bioactive compounds</topic><topic>Biological activity</topic><topic>Biological Techniques</topic><topic>Bioorganic Chemistry</topic><topic>Cell death</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chromatography</topic><topic>Cognitive ability</topic><topic>Column chromatography</topic><topic>Ethanol</topic><topic>High performance liquid chromatography</topic><topic>Hydrogen peroxide</topic><topic>Ionization</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Liquid chromatography</topic><topic>Malondialdehyde</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Memory</topic><topic>Neurodegenerative diseases</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Peroxidation</topic><topic>Pheochromocytoma cells</topic><topic>Quinic acid</topic><topic>Roots</topic><topic>농학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwon, Yoon Kyung</creatorcontrib><creatorcontrib>Choi, Soo Jung</creatorcontrib><creatorcontrib>Kim, Cho Rong</creatorcontrib><creatorcontrib>Kim, Jae Kyeom</creatorcontrib><creatorcontrib>Kim, Youn-Jung</creatorcontrib><creatorcontrib>Choi, Jong Hun</creatorcontrib><creatorcontrib>Song, Sang-Wook</creatorcontrib><creatorcontrib>Kim, Chang-Ju</creatorcontrib><creatorcontrib>Park, Gwi Gun</creatorcontrib><creatorcontrib>Park, Cheung-Seog</creatorcontrib><creatorcontrib>Shin, Dong-Hoon</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Agriculture & Environmental Science Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Biological Sciences</collection><collection>Agricultural Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Korean Citation Index</collection><jtitle>Applied biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwon, Yoon Kyung</au><au>Choi, Soo Jung</au><au>Kim, Cho Rong</au><au>Kim, Jae Kyeom</au><au>Kim, Youn-Jung</au><au>Choi, Jong Hun</au><au>Song, Sang-Wook</au><au>Kim, Chang-Ju</au><au>Park, Gwi Gun</au><au>Park, Cheung-Seog</au><au>Shin, Dong-Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant and cognitive-enhancing activities of Arctium lappa L. roots in Aβ1-42-induced mouse model</atitle><jtitle>Applied biological chemistry</jtitle><stitle>Appl Biol Chem</stitle><date>2016-08-01</date><risdate>2016</risdate><volume>59</volume><issue>4</issue><spage>553</spage><epage>565</epage><pages>553-565</pages><issn>2468-0834</issn><eissn>2468-0842</eissn><abstract>Many studies have shown that oxidative stress induced by hydrogen peroxide can lead to neuronal cell death. In this study, protective effects of the ethanol extract of
A. lappa
L. roots against oxidative stress in PC12 cells were measured by 2′, 7′-dichlorofluorescein diacetate and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Oxidative stress contributes to the memory deficits induced by Beta-amyloid
1-42
in mice. Treatment with the ethanol extract of
A. lappa
L. roots improved working and reference memory in mice in the Y-maze and passive avoidance tests. To detect the lipid peroxidation levels, malondialdehyde was measured. To purify the bioactive compound, active fractions and components of
A. lappa
L. roots were isolated by partitioning, open column chromatography, TLC, high-performance liquid chromatography, electron ionization mass spectrometry, and
1
H/
13
C-nuclear magnetic resonance. We identified the bioactive compound as quinic acid, which is a powerful antioxidant agent. Ultimately, the roots of
A. lappa
L. may become available as an antioxidant food for Alzheimer’s disease patients and those with other oxidative stress-induced disorders.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s13765-016-0195-2</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Applied Biological Chemistry, 2016, 59(4), , pp.553-565 |
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| language | eng |
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| source | Publicly Available Content (ProQuest) |
| subjects | Alzheimer's disease Antioxidants Applied Microbiology Bioactive compounds Biological activity Biological Techniques Bioorganic Chemistry Cell death Chemistry Chemistry and Materials Science Chromatography Cognitive ability Column chromatography Ethanol High performance liquid chromatography Hydrogen peroxide Ionization Lipid peroxidation Lipids Liquid chromatography Malondialdehyde Mass spectrometry Mass spectroscopy Memory Neurodegenerative diseases NMR Nuclear magnetic resonance Oxidation Oxidative stress Peroxidation Pheochromocytoma cells Quinic acid Roots 농학 |
| title | Antioxidant and cognitive-enhancing activities of Arctium lappa L. roots in Aβ1-42-induced mouse model |
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