Suppression of MicroRNA let-7a Expression by Agmatine Regulates Neural Stem Cell Differentiation

Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies ha...

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Bibliographic Details
Published in:Yonsei medical journal 2016, 57(6), , pp.1461-1467
Main Authors: Song, Juhyun, Oh, Yumi, Kim, Jong Youl, Cho, Kyoung Joo, Lee, Jong Eun
Format: Article
Language:English
Subjects:
Agmatine - pharmacology
Cell Differentiation - drug effects
Cell Proliferation
Humans
MicroRNAs - metabolism
Neural Stem Cells - cytology
Neural Stem Cells - drug effects
Neurogenesis - drug effects
Neurons - cytology
Neurons - drug effects
Neurons - metabolism
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의학일반
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Summary:Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.
ISSN:0513-5796
1976-2437
DOI:10.3349/ymj.2016.57.6.1461