Hashimoto thyroiditis with an unusual presentation of cardiac tamponade in Noonan syndrome

• Published in: Clinical and experimental pediatrics 2016, 59(0), , pp.112-115
• Main Authors: Lee, Mi Ji, Kim, Byung Young, Ma, Jae Sook, Choi, Young Earl, Kim, Young Ok, Cho, Hwa Jin, Kim, Chan Jong
• Format: Article
• Language: English
• Subjects: Abdomen; Antibodies; Autoimmune diseases; Blood pressure; Cardiac tamponade; Case Report; Catheters; Conflicts of interest; Congenital diseases; Cryptorchidism; Genes; Hashimoto thyroiditis; Heart; Hypothyroidism; Intellectual disabilities; Laboratories; Laparotomy; Mutation; Noonan syndrome; Patients; Pericardial effusion; Proteins; Thyroid gland; Ultrasonic imaging; 소아과학
• ISSN: 1738-1061; 2092-7258; 2713-4148
• DOI: 10.3345/kjp.2016.59.11.S112

Noonan syndrome is an autosomal dominant, multisystem disorder. Autoimmune thyroiditis with hypothyroidism is an infrequent feature in patients with Noonan syndrome. A 16-year-old boy was admitted because of chest discomfort and dyspnea; an echocardiogram revealed pericardial effusion. Additional investigations led to a diagnosis of severe hypothyroidism due to Hashimoto thyroiditis. The patient was treated with L-thyroxine at 0.15 mg daily. However, during admission, he developed symptoms of cardiac tamponade. Closed pericardiostomy was performed, after which the patient's chest discomfort improved, and his vital signs stabilized. Herein, we report a case of an adolescent with Noonan syndrome, who was diagnosed with Hashimoto thyroiditis with an unusual presentation of cardiac tamponade.