A 2-month-old boy with hemolytic anemia and reticulocytopenia following intravenous immunoglobulin therapy for Kawasaki disease: a case report and literature review

Herein, we report a rare case of hemolytic anemia with reticulocytopenia following intravenous immunoglobulin therapy in a young infant treated for Kawasaki disease. A 2-month-old boy presented with fever lasting 3 days, conjunctival injection, strawberry tongue, erythematous edema of the hands, and...

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Bibliographic Details
Published in:Clinical and experimental pediatrics 2016, 59(0), , pp.60-63
Main Authors: Kim, Na Yeon, Kim, Joon Hwan, Park, Jin Suk, Kim, Soo Hyun, Cho, Yeon Kyung, Cha, Dong Hyun, Kim, Ki Eun, Kang, Myung Suh, Lim, Kyung Ah, Sheen, Youn Ho
Format: Article
Language:English
Subjects:
Anemia
Apoptosis
Blood
Blood platelets
Bone marrow
Case Report
Conflicts of interest
Cytomegalovirus
Electrocardiography
Fever
Hemoglobin
Hemolysis
Herpes viruses
Immunoglobulins
Iron
Kawasaki disease
Laboratories
Patients
Reticulocytes
Rubella
Ultrasonic imaging
Viral infections
소아과학
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Summary:Herein, we report a rare case of hemolytic anemia with reticulocytopenia following intravenous immunoglobulin therapy in a young infant treated for Kawasaki disease. A 2-month-old boy presented with fever lasting 3 days, conjunctival injection, strawberry tongue, erythematous edema of the hands, and macular rash, symptoms and signs suggestive of incomplete Kawasaki disease. His fever resolved 8 days after treatment with aspirin and high dose infusion of intravenous immunoglobulin. The hemoglobin and hematocrit decreased from 9.7 g/dL and 27.1% to 7.4 g/dL and 21.3%, respectively. The patient had normocytic hypochromic anemia with anisocytosis, poikilocytosis, immature neutrophils, and nucleated red blood cells. The direct antiglobulin test result was positive, and the reticulocyte count was 1.39%. The patient had an uneventful recovery. However, reticulocytopenia persisted 1 month after discharge.
ISSN:1738-1061
2092-7258
2713-4148
DOI:10.3345/kjp.2016.59.11.S60