Quercetin 7-O-Glutamate Sensitizes P. aeruginosa to β-Lactams and Vancomycin

In this study, quercetin and its conjugates with pivaloxymethyl, glutamic acid, or alanine promoieties were evaluated for their ability to sensitize wild type P. aeruginosa to β‐lactam antibiotics. Among the quercetin conjugates, quercetin 7‐O‐glutamate was as potent as phenylalanine‐arginine β‐naph...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2016, 37(12), , pp.2025-2028
Main Authors: Kim, Mi Kyoung, Park, Kwang-su, Jung, Woong, Choo, Hyunah, Chong, Youhoon
Format: Article
Language:English
Subjects:
P. aeruginosa
Quercetin conjugate
Sensitization
Vancomycin
β-lactam
화학
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Summary:In this study, quercetin and its conjugates with pivaloxymethyl, glutamic acid, or alanine promoieties were evaluated for their ability to sensitize wild type P. aeruginosa to β‐lactam antibiotics. Among the quercetin conjugates, quercetin 7‐O‐glutamate was as potent as phenylalanine‐arginine β‐naphthylamide (PAβN), and addition of this conjugate (25 µg/mL) resulted in significant reduction of minimum inhibitory concentrations (MICs) of the β‐lactam antibiotics such as piperacillin, cefotaxime, and ceftazidime (two‐, four‐, and eight‐fold, respectively). Quercetin 7‐O‐glutamate was also effective in sensitizing P. aeruginosa to bulky antibiotics such as vancomycin and erythromycin through permeabilization of the outer membrane of the Gram‐negative bacterium. The outer membrane‐destabilizing activity of 7‐O‐glutamate was similar to that of PAβN, and it decreased the MICs of both vancomycin and erythromycin by 16‐fold.
ISSN:1229-5949
0253-2964
1229-5949
DOI:10.1002/bkcs.11023