Diversification of Indoles via Microwave-assisted Ligand-free Copper-catalyzed N-Arylation

A simple, efficient Cu2O catalyst system under microwave irradiation was developed for N‐arylation of various indoles without ligands and additives. Diverse N‐heteroarylated indoles were prepared by coupling indoles with various heteroaryl halides within 1 h. The selective reactivity of bromoindole...

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Published in:Bulletin of the Korean Chemical Society 2016, 37(12), , pp.1927-1933
Main Authors: Kwon, Jae-Kwan, Lee, Jin -Hee, Kim, Tae Sung, Yum, Eul Kgun, Park, Hee Jung
Format: Article
Language:English
Subjects:
Cu2O
Indole
Ligand-free
Microwave
N-arylation
화학
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container_end_page 1933
container_issue 12
container_start_page 1927
container_title Bulletin of the Korean Chemical Society
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creator Kwon, Jae-Kwan
Lee, Jin -Hee
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description A simple, efficient Cu2O catalyst system under microwave irradiation was developed for N‐arylation of various indoles without ligands and additives. Diverse N‐heteroarylated indoles were prepared by coupling indoles with various heteroaryl halides within 1 h. The selective reactivity of bromoindole with aryl iodide provided N‐aryl bromoindoles, which could be useful intermediates for palladium‐catalyzed Heck and Suzuki coupling reactions.
doi_str_mv 10.1002/bkcs.10995
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subjects Cu2O
Indole
Ligand-free
Microwave
N-arylation
화학
title Diversification of Indoles via Microwave-assisted Ligand-free Copper-catalyzed N-Arylation
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