Preparation of Hydroxypropyl Cyclosophoraose/Dextran Microspheres for the Controlled Release of Ciprofloxacin

Hydroxypropyl cyclosophoraose/dextran (HPCys/dextran) microspheres were prepared using an emulsion polymerization method for use as drug carriers to achieve the controlled release of a poorly water‐soluble antibacterial drug, ciprofloxacin (CFX). Cyclosophoraoses are cyclic (1 → 2)‐β‐d‐glucans isola...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2016, 37(12), , pp.1947-1954
Main Authors: Lee, Benel, Jeong, Daham, Joo, Sang-Woo, Choi, Jae Min, Lee, Jae Yung, Cho, Eunae, Park, Seyeon, Jung, Seunho
Format: Article
Language:English
Subjects:
Ciprofloxacin
Controlled release
Dextran
Hydroxypropyl cyclosophoraose
Micropshere
화학
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Summary:Hydroxypropyl cyclosophoraose/dextran (HPCys/dextran) microspheres were prepared using an emulsion polymerization method for use as drug carriers to achieve the controlled release of a poorly water‐soluble antibacterial drug, ciprofloxacin (CFX). Cyclosophoraoses are cyclic (1 → 2)‐β‐d‐glucans isolated from the Rhizobium species. Characteristics of HPCys/dextran microspheres were investigated using Fourier transform infrared analysis, solid‐state 13C nuclear magnetic resonance spectroscopy, and field emission scanning electron microscopy. The amount of CFX released from these microspheres at pH 7.4 (intestinal phase pH) was about two times higher than that released at pH 1.2 (gastric phase pH). Furthermore, HPCys/dextran microspheres did not show any toxicity in human embryonic kidney cells. We propose that HPCys/dextran microspheres could be used as an effective pH‐dependent release system for poorly water‐soluble drugs such as CFX.
ISSN:1229-5949
0253-2964
1229-5949
DOI:10.1002/bkcs.11001