Effects of Distilled Cervi Pantotrichum Cornu and Rehmannia glutinosa Pharmacopuncture at GB21 (Jianjing) on Heart Rate Variability: A Randomized and Double-blind Clinical Trial

The purpose of this study was to use heart rate variability (HRV) to investigate the effects of distilled Cervi Pantotrichum Cornu pharmacopuncture and Rehmannia glutinosa pharmacopuncture on the autonomic nervous system. Forty healthy male participants were divided into two groups: the participants...

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Bibliographic Details
Published in:Journal of acupuncture and meridian studies 2016, 9(6), 44, pp.311-318
Main Authors: Kim, Young-Joo, Lee, Chang-Hyun, Kim, Jong-Uk, Yook, Tae-Han
Format: Article
Language:English
Subjects:
Acupuncture
Acupuncture Points
Autonomic Nervous System - drug effects
Autonomic Nervous System - physiology
Cervi Pantotrichum Cornu
Cornus - chemistry
Female
Heart Rate - drug effects
heart rate variability
Humans
Injections
Korean medicine
Male
pharmacopuncture
Plant Extracts - administration & dosage
Rehmannia - chemistry
Rehmannia glutinosa
Republic of Korea
한의학
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Summary:The purpose of this study was to use heart rate variability (HRV) to investigate the effects of distilled Cervi Pantotrichum Cornu pharmacopuncture and Rehmannia glutinosa pharmacopuncture on the autonomic nervous system. Forty healthy male participants were divided into two groups: the participants of the C-group received distilled Cervi Pantotrichum Cornu pharmacopuncture and those of the R-group received Rehmannia glutinosa pharmacopuncture. The study design was a randomized, double-blind clinical trial. Each participant received one of the two solutions injected at GB21 (Jianjing). The changes in HRV were measured seven times using the QECG-3: LXC3203 system (LAXTHA Inc. Korea). Time-dependent changes in HRV for each group were analyzed using the paired t test (significance level: p < 0.05), and the difference in the HRV fluctuations between the two experimental groups was evaluated using the independent sample test (significance level: p < 0.05). The results showed that Cervi Pantotrichum Cornu pharmacopuncture and Rehmannia glutinosa pharmacopuncture tended to activate the autonomic nervous system within the normal range. Cervi Pantotrichum Cornu pharmacopuncture tended to activate the sympathetic nervous system, whereas Rehmannia glutinosa pharmacopuncture tended to activate both the sympathetic and parasympathetic nervous systems.
ISSN:2005-2901
2093-8152
DOI:10.1016/j.jams.2016.11.001