Crystalline podocytopathy and tubulopathy without overt glomerular proteinuria in a patient with multiple myeloma

Crystalline nephropathy is a rare yet well-known condition associated with multiple myeloma and other light chain–secreting disorders. Paraproteins that are resistant to proteolysis crystallize within proximal tubular cells and cause light-chain proximal tubulopathy, which presents clinically as Fan...

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Published in:Kidney research and clinical practice 2016, 35(4), , pp.259-262
Main Authors: Lee, Eun Jeong, Lee, Su Yeon, Park, So Young, Kim, Yonjin, Choi, Jae Shin, Kim, Mi Jeoung, Park, Ji Hyeon, Lee, Jung Eun, Kwon, Ghee Young, Kim, Yoon-Goo
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Language:English
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Case Report
Fanconi syndrome
Multiple myeloma
Nephropathy
내과학
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cited_by cdi_FETCH-LOGICAL-c625t-f5e63105b6d12d9efad9471861a814988655c17c4fb933f90b4b4c0e09424cbd3
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container_title Kidney research and clinical practice
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creator Lee, Eun Jeong
Lee, Su Yeon
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Kwon, Ghee Young
Kim, Yoon-Goo
description Crystalline nephropathy is a rare yet well-known condition associated with multiple myeloma and other light chain–secreting disorders. Paraproteins that are resistant to proteolysis crystallize within proximal tubular cells and cause light-chain proximal tubulopathy, which presents clinically as Fanconi syndrome. Podocytes are rarely affected, and the crystalline inclusions within podocytes are typically precipitated, yielding significant glomerular proteinuria. Here we report a case of extensive crystalline inclusions primarily within podocytes and proximal tubules that presented only with Fanconi syndrome and renal insufficiency. Despite the presence of extensive crystalline inclusions in podocytes and diffuse foot process effacement, the patient had no clinical evidence suggestive of podocyte injury.
doi_str_mv 10.1016/j.krcp.2016.06.001
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subjects Case Report
Fanconi syndrome
Multiple myeloma
Nephropathy
내과학
title Crystalline podocytopathy and tubulopathy without overt glomerular proteinuria in a patient with multiple myeloma
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