The Discovery of Novel Protein Tyrosine Phosphatase ε Inhibitors Using a High‐throughput Screening Approach

Protein tyrosine phosphatase epsilon (PTPε) is important for signal transduction in osteoclasts, and is considered to be an attractive drug target for the treatment of osteoporosis. We identified 11 potent PTPε inhibitors based on three chemical scaffolds through the high‐throughput screening of a c...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2017, 38(1), , pp.44-53
Main Authors: Yun, Hye‐Yeoung, Ku, Bonsu, Lee, Hye Seon, Shin, Ho‐Chul, Park, Jun‐Beom, Kim, Chang Hyen, Kim, Seung Jun
Format: Article
Language:English
Subjects:
Chemical library
High‐throughput screening
Inhibitor
Osteoporosis
Protein tyrosine phosphatase
화학
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Summary:Protein tyrosine phosphatase epsilon (PTPε) is important for signal transduction in osteoclasts, and is considered to be an attractive drug target for the treatment of osteoporosis. We identified 11 potent PTPε inhibitors based on three chemical scaffolds through the high‐throughput screening of a chemical library. As these compounds are structurally diverse with high bioavailability, they warrant further investigation in the near future. The discovery of these inhibitors and the relationship between their structure and inhibitory activity toward PTPε is discussed in detail.
ISSN:1229-5949
0253-2964
1229-5949
DOI:10.1002/bkcs.11044